摘要
目的考察了碱敏感型聚合物瓜耳胶-g-丙烯酰胺-丙烯酸(GPAA)的平衡溶胀及动力学溶胀性质。方法用吸水量衡量GPAA的溶胀能力。结果溶胀介质的pH、离子强度及聚合物的单体组成均影响聚合物的溶胀性质;GPAA骨架片的平衡溶胀率随pH的增加而增加,并且存在2个突跃点,即pH3.0与pH6.8;随着聚合物中AAc含量的增加,凝胶达到溶胀平衡的时间从4.5h增加至10.5h,并且吸水溶胀能力大大增强;随着离子强度从0.1增加到1.0,凝胶达到溶胀平衡的时间从9.5h缩短至7.5h。平衡溶胀率从6.8819减小至3.0962。结论GPAA溶胀性质结果表明,GPAA溶胀具有明显的pH依赖性。
Abstract
OBJECTIVE To investigate the swelling properties of(Guar gum-g-P acrylamide-acryacid)GPAA hydrogel.METHODS The courses of hydrogel swelling were analyzed by fitting the experimental dates with mathematical models,such as Vergnaud model.The swelling rate was caculated in terms of the second swelling dynamics equation of Schott.RESUITS The equilibrium-swelling ratio of GPAA impulse control release tablets was increased with the increasing pH of medium.At pH 3.0 and pH 6.8,the equilibrium-swelling ratio had obvious change.With the increasing of the AAc content in the polyer from 50% to 70%,the quilibrium-swelling ratio of hydrogel was increased,the sopping ability of hydrogel was increased.It took 9.5 h for the hydrogel to swell completely in medium with the ion strength of 0.1,but it only took 7.5 h for hydrogel to swell completely in medium with the ion strength of 1.0.The equilibrium-swelling ratio of hydrogel was decreased from 6.881 9 to 3.096 2,the sopping ability of hydrogel took off.CONCLUSION The phchange of medium can effect obviously the swelling of GPAA.
关键词
pH敏感 /
平衡溶胀 /
动力学溶胀
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Key words
phsensitive /
equilibrium-swelling /
dynamics-swelling
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郎轶咏;李三鸣;郑梁元.
pH敏感型接枝共聚物瓜耳胶-g-丙烯酰胺-丙烯酸溶胀性质研究[J]. 中国药学杂志, 2008, 43(10): 762-765
LNG Yi-yong;LI Sn-ming;ZHENG Ling-yun.
Study on Swelling Property of pH Sensitive Polymer of Guar Gum-g-P Acrylamide-Acrylacid [J]. Chinese Pharmaceutical Journal, 2008, 43(10): 762-765
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参考文献
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脚注
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