目的研究在全麻手术患者中硫喷妥钠对丙泊酚药动学的影响,并与单用丙泊酚时比较。方法16名全麻手术患者分为2组,分别静注丙泊酚2mg·kg^-1或1%丙泊酚和2.5%硫喷妥钠1:1等体积混合液0.2mL·kg^-1(相当于丙泊酚1mg·kg^-1,硫喷妥钠2.5mg·kg^-1),用高效液相色谱法测定丙泊酚血药浓度。用3P97程序拟合计算药动学参数。结果静注丙泊酚的药-时曲线符合三室模型,单用组与合用组的药动学参数:t_1/2α分别为(0.8±0.4)和(0.7±0.3)min,t_1/2β分别为(10.2±15.6)和(6.5±5.0)min,t_1/2γ分别为(113.0±47.2)和(159.0±82.5)min,V_c分别为(0.055±0.022)和(0.052±0.041)L·kg^-1,CL分别为(17.4±4.5)和(15.5±8.3)mL·h^-1·kg^-1,AUC分别为(108.92±31.68)和(88.84±59.08)mg.min·L^-1。结论二组患者间丙泊酚主要药动学参数的差异无统计学意义,与文献报道基本一致。

OBJECTIVE To study the effect of thiopental on pharmacokinetics of propofol in patients undergoing general anesthesia.METHODS 16 Patients undergoing general anesthesia were divided into 2 groups randomly.After intravenous administration of propofol 2 mg·kg^-1 or 1% propofol and 2.5% thiopental in a ratio of 1:1 volume mixture,the serum concentrations of propofol were measured by high performance liquid chromatography.The pharmacokinetic parameters of propofol were estimated by 3P97 program.RESULTS The serum concentration-time profiles of propofol were discribed by a three compartment model.The pharmacokinetic parameters for two groups were as follows:t_1/2α(0.8±0.4) and(0.7±0.3)min,t_1/2β(10.2±15.6) and(6.5±5.0) min,t_1/2γ(113.0±47.2) and(159.0±82.5) min,V_c(0.055±0.022) and(0.052±0.041) L·kg^-1,CL(17.4±4.5) and(15.5±8.3) mL·h^-1·kg^-1,AUC(108.92±31.68) and(88.84±59.08) mg·min·L^-1,respectively.CONCLUSION No significant differences were found among the main pharmacokinetic parameters in two groups,which is in good accordance with that of the literature reports.