摘要
目的研究淫羊藿中黄酮类化合物在大鼠各肠段的吸收动力学特征。方法采用大鼠在体肠灌流模型对淫羊藿苷和淫羊藿总黄酮在大鼠各肠段的吸收特性进行研究。结果淫羊藿苷在大鼠各肠段的渗透系数按空肠、十二指肠、回肠、结肠顺序依次分别为(5.25±0.17),(4.27±0.28),(1.99±0.09),(0.80±0.03);淫羊藿总黄酮中淫羊藿苷在大鼠各肠段的渗透系数按空肠、十二指肠、回肠、结肠顺序依次分别为(3.65±0.18),(4.68±0.17),(1.64±0.08),(0.58±0.26)。结论淫羊藿总黄酮中有多种成分在大鼠肠段会发生代谢转化,其中淫羊藿苷经过大鼠肠段后代谢最为明显。
Abstract
OBJECTIVE To investigate the absorption characteristics and mechanism of the total flavones of epimedium for various intestinal segments.METHODS The intestine in rats was cannulated for in situ recirculation.RESULTS Icariin was metabolized quickly in the four intestinal segments.The permeability coefficients(Peff) were(5.25±0.17),(4.27±0.28),(1.99±0.09) and(0.80±0.03) at duodenum,jejunum,ileum and colon,respectively,and the permeability coefficients(Peff) of Icariin in the total flavones of epimedium were(3.65±0.18),(4.68±0.17),(1.64±0.08) and(0.58±0.26) at duodenum,jejunum,ileum and colon,respectively.CONCLUSION Some compositions of the total flavones of epimedium show metabolic transformation,and Icariin shows obviously metabolism.
关键词
淫羊藿苷 /
淫羊藿总黄酮 /
吸收动力学 /
在体肠灌流模型
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Key words
icariin /
total flavones of epimedium /
absorption-kinetic /
in situ perfused rat intestinal model
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赵艳红;贾晓斌;陈彦;范晨怡 Ming H.
淫羊藿黄酮类化合物的大鼠在体肠吸收研究[J]. 中国药学杂志, 2008, 43(03): 188-191
ZHO Yn-hong;JI Xio-in;CHEN Yn;FN Chen-yi;MING Hu.
Studies on Rat Intestinal Absorption of the Total Flavones of Epimedium in Situ [J]. Chinese Pharmaceutical Journal, 2008, 43(03): 188-191
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参考文献
[1] Ch.P VolⅠ(中国药典2005年版.一部) [S] . 2005：229.
[2] LI Z Z，XU Y Q，WANGY，et al. Status and prospect of research on medicinal plants of Epimedium L [J] .Chin Tradit Herb Drugs(中草药)，2005，36(2)：289-295.
[3] ZHAO Y H，ABRAHAM M H，LE J，et al. Evaluation of rat intestinal absorption data and correlation with human intestinal absorption [J] .Eur J Med Chem，2003，38(3)：233-243.
[4] TAO J Y，XU S X，LI Z X，et al. Study on Extraction Process of Epimedium[J] .Li Shizhen Med Mater Med Res(时珍国医国药)，2004，15(1)： 11-12.
[5] CHEN J，LIN H M，HU M.Metabolism of flavonoids via enteric recycling： Role of intestinal disposition[J] .J Pharm Exp Ther，2003，304(3)：1228-1235.
[6] LIU Y，LIU Y.Enteric Disposition and Recycling of Flavonoids and Ginkgo Flavonoids[J] .J Altern Complement Med，2003，9(5)：631-640.
[7] JIA X B，CHEN J，LIN H M，et al. Disposition of flavonoids via enteric recycling： enzyme-transporter coupling affects metabolism of Biochanin A and Formononetin and excretion of their phase Ⅱ conjugates[J] .J Pharm Exp Ther，2004，310(3)：1103-1113.
[8] QIU F，CHEN YJ，KANO Y，et al. Metabolism of orally administered icariin in rats[J] .Acta Pharm Sin (药学学报)，1999，34(3)：222-226.
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脚注
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基金
国家自然科学基金资助项目(30572372);江苏省国际合作计划项目(BZ2006059);江苏省中医药局科学技术研究专项项目(H05120)
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