抗肝纤维化药物研究新进展

蔡卫民

中国药学杂志 ›› 2008, Vol. 43 ›› Issue (03) : 161-164.

中国药学杂志 ›› 2008, Vol. 43 ›› Issue (03) : 161-164.
综述

抗肝纤维化药物研究新进展

  • 蔡卫民
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摘要

目的概述肝纤维化新概念,抗肝纤维化新认识与新分类,抗肝纤维化治疗的适应证与常用药物介绍。方法以近几年有代表性的论文为依据,进行分析,整理和归纳。结果与结论应从形态学、生化学、细胞学、免疫学、分子生物学全面认识肝纤维化,抗肝纤维化治疗需与去除病因(例如抗病毒)治疗相结合,治疗目的是预防肝纤维化的发生(抗肝损),抑制肝纤维化的形成(针对HSC)与促进肝纤维化的降解。临床证实,IFN-γ治疗9个月部分患者(5/26)代偿性肝硬化者假小叶消失。扶正化瘀胶囊片、复方鳖甲软肝片、复方牛胎肝提取物片(安珐特)也有较好的临床效果。但仍缺乏大样本、多中心、随机、双盲对照比较研究。

关键词

肝纤维化 / 抗肝纤维化药物

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导出引用
蔡卫民. 抗肝纤维化药物研究新进展[J]. 中国药学杂志, 2008, 43(03): 161-164

参考文献

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基金

国家自然科学基金资助(30571664);总理专项基金(94-y-17)

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