[1] POURNARAS S,MANIATI M,PETINAKI E,et al.Hospital outbreak of multiple clones of Pseudomonas aeruginosa carrying the unrelated metallo-beta-lactamase gene variants blaVIM-2 and blaVIM-4[J ] . J Antimicrob Chemother,2003,51(6): 1409-1414.
[2] DODDAREDDY M R,CHA J H,CHO Y S,et al. Volsurf analysis of carbapenem antibiotics[J] . Bioorg Med Chem,2005,13 (10): 3339-3349.
[3] CHUKWUEMEKA S,OKEREK E. Advance in the use of carbapenem antibiotics in the management of serious bacterial infectious in special patient populations. I: safety and efficacy in children and elderly patients[J] . Curr Ther Res Clin Exp,2000,61(5): 289-320.
[4] OH C H,LEE S C,CHO J H,Synthesis and antibacterial activity of 1β-methyl -2- [5- (N - substituted-2-hydroxy iminoethyl)pyrrolidin-3-ylthio] carbapenem derivatives[J] . Eur J Med Chem,2003,38(7-8): 751-758.
[5] LEE J S,CHOA J H,CHO H,et al. Synthesis and antibacterial evaluation of 1β -methyl -2-(5 -substituted heterocyclic carbamoyl)pyrrolidin-3-ylthio)carbapenem derivatives[J] . Arch Pharm (Weinheim),2004,337(7): 391-397.
[6] CHO H W,OH C H,LEE J S,et al. Synthesis and antibacterial activities of 4-pyrrolidinylthio carbapenems: containing heteroaromatics as a side chain[J] . Arch Pharm (Weinheim),2003,336(11): 495-503.
[7] OH C H,CHO J H. Synthesis and biological evaluation of 1β-methyl carbapenems having guanidino moieties[J] . Eur J Med Chem,2006,41(1): 50-55.
[8] LEVINE D P,FROMM B S,REDDY B R. Slow response to vancomycin or vancomycin plus rifampin in methicillin-resistant Staphylococcus aureus endocarditis[J] . Ann Intern Med,1991,115(9): 674-680.
[9] NAGANO R,SHIBATA K,DACHI Y,et al. In vitro activities of novel trans-3,5-disubstituted pyrrolidinylthio-1β-methylcarbapenems with potent activities against methicillin-resistant Staphylococcus aureus and Pseudomonas aeruginosa[J] . Antimicrob Agents Chemother,2000,44(3): 489-495.
[10] IMAMURA H,OHTAKE N,SHIMIZU A. et al. Structure-activity relationships of trans-3,5- disubstituted pyrrolidinylthio-1beta-methylcarbapenems. Part 1: J-111,347 and related compounds [J] . Bioorg Med Chem Lett,2000,10(2): 109-113.
[11] SUMITA Y,NOUDA H,KANAZAWA K,et al. Antimicrobial activity of SM-17466,a novel carbapenem antibiotic with potent activity against methicillin-resistant Staphylococcus aureus[J] . Antimicrob Agents Chemother,1995,39(4): 910-916.
[12] UEDA Y,SUNAGAWA M. In vitro and in vivo activities of novel 2-(thiazol-2-ylthio) -1β - methylcarbapenems with potent activities against multiresistant Gram-positive bacteria[J] . Antimicrob Agents Chemother,2003,47(8): 2471-2480.
[13] UEDA Y,ITOH M,SASAKI A,et al. SM-216601,a novel parenteral 1beta-methylcarbapenem: structure-activity relationships of antibacterial activity and neurotoxicity in mice[J] . J Antibiot (Tokyo),2005,58(2): 118-140.
[14] UEDA Y,KANAZAWA K,EQUCHI K. et al. In vitro and In Vivo antibacterial activities of SM-216601,a new broad-spectrum parenteral carbapenem[J] . Antimicrob Agents Chemother,2005,49(10): 4185-4196.
[15] SUNAGAWA M,ITOH M,KUBOTA K. et al. New anti-MRSA and anti-VRE carbapenems: synthesis and structure-activity relationships of 1beta-methyl-2-(thiazol-2-ylthio) carbapenems[J] . J Antibiot (Tokyo),2002,55(8): 722-757.
[16] WEISS W J,PETERSEN P J,JACOBUS N V. et al. In vitro activities of aminomethyl-substituted analogs of novel tetrahydrofuranyl carbapenems[J] . Antimicrob Agents Chemother,1999,43(3): 454-459.
[17] JIRASKOVA N . THF carbapenems. Wyeth Ayers[J] . Curr Opin Investig Drugs,2001,2(8): 1035-1038.
[18] NORRBY S R. Neurotoxicity of carbapenem antibiotics:consequences for their use in bacterial meningitis[J] . Antimicrob Agents Chemother,2000,45(1): 5-7.
[19] JIN C,JUNG I,KU H J,et al. Low convulsive activity of a new carbapenem antibiotic,DK-35C,as compared with existing congeners[J] . Toxicology,1999,138(2): 59-67.
[20] HORIUCHI M,KIGUMI M,TOKUMUR A. et al. Absence of convulsive liability of doripenem,a new carbapenem antibiotic,in comparison with β-lactam antibiotics[J] . Toxicology,2006,222(1-2): 114-124.