摘要
目的总结目前临床应用的抗抑郁药物与其他药物合用时可能发生的不良药物相互作用,提请临床注意避免或谨慎合用。方法通过检索Medline、中国期刊全文数据库(CNKI)等检索源,总结和分析药物之间的相互作用情况。结果抗抑郁药物大多数要通过肝脏细胞色素P450(CYP)酶系代谢,其原型药物或/和代谢物可能具有CYP酶抑制或诱导作用,对合用的部分药物可能产生有临床意义的不良相互作用。结论临床应该谨慎或避免这些药物合用,并且在更换治疗药物时要充分考虑药物的清洗期长短,做到安全、有效、合理用药。
关键词
抗抑郁药物 /
药物相互作用 /
选择性5-羟色胺再摄取抑制剂 /
氟西汀
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刘治军;傅得兴;孙春华;迟家敏;陈乃宏.
抗抑郁药物相关的药物相互作用[J]. 中国药学杂志, 2007, 42(06): 409-414
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脚注
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