摘要
目的研究豨莶草乙酸乙酯部位中化学成分。方法采用硅胶柱色谱等色谱技术分离和纯化化合物,根据化合物的理化性质和运用波谱技术解析鉴定结构。结果从豨莶草乙酸乙酯部位中分离得到7个化合物,其中1个查尔酮类化合物为3′,5′,β-三羟基-3,4,4′,α-四甲氧基查儿酮(3′,5′,β-trihydroxy-3,4,4′,α-tetramethoxy-chalcone,1),5个二萜类成分分别为奇任醇(kirenol 2),豨莶精醇(darutigenol 3),豨莶酸(siegesbeckicacid 4),对映-16β,17-二羟基贝壳杉烷-19-羧酸(ent-16β,17-dihydroxy-19-kauranoicacid 5),对映-17-羟基贝壳杉烷-19-羧酸(ent-16αH-17-hydroxy-19-kauranoicacid 6),1个甾醇类化合物为豆甾醇(stig-masterol 7)。结论3′,5′,β-三羟基-3,4,4′,α-四甲氧基查儿酮为新化合物。
Abstract
OBJECTIVE To study the chemical constituents in the ethyl acetate fraction of Herba Siegesbeckiae.METHODS Compounds were isolated and purified by silica gel columns and MPLC, and their structures were identified by the physicochemical properties and spectral analysis. RESULTS Seven compounds were isolated and elucidated as 3′, 5′,β-trihydroxy-3,4,4′,α-tetramethoxy-chalcone(1),kirenol(2),darutigenol(3),siegesbeckic acid(4),ent-16β,17-dihydroxy-19-kauranoic acid(5),ent-16αH-17-hydroxy-19-kauranoic acid(6) and stigmasterol(7).CONCLUSION Compound 1 is the new compound.
关键词
豨莶草 /
二萜 /
查尔酮
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Key words
Herba Siegesbeckiae L. /
diterpenoids /
chalcone
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侴桂新;王峥涛.
豨莶草化学成分研究[J]. 中国药学杂志, 2006, 41(24): 1854-1857
CHOU Gui-xin;WNG Zheng-to.
Study on Chemical Constituents of Herba Siegesbeckiae[J]. Chinese Pharmaceutical Journal, 2006, 41(24): 1854-1857
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参考文献
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脚注
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基金
上海市高等学校科学技术发展基金项目(2000C03);上海市中药学重点学科建设项目资助(Y0301);国家中医药管理局中医药科技重大项目(02代08)
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