1.Chinese Medicine College，Xinjiang Medical University，Urumqi 830054，China；2.Institute of Applied Chemistry，Southwest University of Science and Technology，Mianyang 621010，China；3.Chengdu Institute of Biology，Chinese Academy of Sciences，Chengdu 610041，China
OBJECTIVE To study the diterpene alkaloids from the roots of Aconitum flavum Hand.-Mazz. METHODS Diterpene alkaloids were isolated by silica gel column,and identified by physicochemical data and spectral methods.RESULTS Eleven diterpene alkaloids were isolated and identified as 3-deoxyaconitine(Ⅰ),3-deoxyaconine-8-linoleate(Ⅱ),3-acetylaconitine(Ⅲ),16,17-dihydro-12β,16β-epoxynapelline(Ⅳ),neoline(Ⅴ),songorine(Ⅵ),aconine-8-linoleate(Ⅶ),aconitine(Ⅷ),12-epi-napelline(Ⅸ),napelline(Ⅹ) and 6-O-demethylneoline(Ⅺ). CONCLUSION Diterpene alkaloids are the main chemical constituents of A.flavum,and compound Ⅱ,Ⅳ～Ⅶ and Ⅺ are found in this plant for the first time.
ZHNG Fn;WNG Xing-ming;PENG Shu-lin;DING Li-sheng.
Study on Diterpene Alkaloids from the Roots of Aconitum flavum[J]. Chinese Pharmaceutical Journal, 2006, 41(24): 1851-1853
{{custom_sec.title}}
{{custom_sec.title}}
{{custom_sec.content}}
参考文献
[1] Flora of China Editorial Board，Chinese Academy of Sciences.Flora of China(1979)，vol 27(中国植物志1979年版.27卷)[M] . Beijing：Science Press，1979：318.
[2] LI H G，YANG J P，TIAN Y J，et al. Studies on the alkaloids of the flower，stem，leaf of yellow Monkshood(Aconitum flavum) [J] .Chin Tradit Herb(中草药)，1997，28(5)：265-266.
[3] CHEN Z G，LAO A N，WANG H C，et al. Continuing investigation on the constituents from Aconitum flavum[J] .Heterocycles，1989，29(6)：997-999.
[4] ZHU Z Q，CHENG D L，CHANG G T，et al. Studies on the alkaloids of Aconitum flavum[J] .China J Chin Mater Med(中国中药杂志)，1981：25-27.
[5] KITAGAWA I，YOSHIKAWA M，CHEN Z L，et al. Four new lipo-alkaloids from Aconiti tuber[J] .Chem Pharm Bull，1982，30(2)：758.
[6] ZHANG F，PENG S L，LIAO X，et al. Three new diterpene alkaloids from the roots of Aconitum nagarum var. lasiandrum[J] .Planta Medica，2005，71：1073-1076.
[7] PELLETIER S W，DJARMATI Z. Carbon-13 nuclear magnetic resonance： aconitine-type diterpenoid alkaloids from Aconitum and Delphinium species[J] .J Am Chem Soc，1976，98(4)：2626-2627.
[8] GABRIEL F，MATIAS R，EMIR V，et al. The diterpenoid alkaloids from Aconitum napellus[J] .Heterocycles，1988，27(5)：1109-1111.
[9] WADA K，BANDO H，AMIYA T，et al. Studies on aconitum species.Two new diterpenoid alkaloids from Aconitum yesoense var.macroyesoense(nakai) [J] .Heterocycles，1989，29(11)：2141-2142.
[10] KONNO C，SHIRASAKA M，HIKINO H. Structure of senbusine A，B and C，diterpenie alkaloids of Aconitum carmichaeli roots from China[J] .J Nat Prod，1982，45(2)：128-130.
