摘要
目的研究伏毛铁棒锤根部的二萜生物碱成分。方法采用正、反相硅胶柱色谱分离纯化,根据理化性质和波谱数据鉴定结构。结果从伏毛铁棒锤根部的乙醇提取物中分离鉴定出11个二萜生物碱,分别为3-脱氧乌头碱(Ⅰ)、3-脱氧乌头原碱-8-亚油酸酯(Ⅱ)、3-乙酰乌头碱(Ⅲ)、16,17-二氢-12β,16β-环氧欧乌头碱(Ⅳ)、尼奥灵(Ⅴ)、宋果灵(Ⅵ)、乌头原碱-8-亚油酸酯(Ⅶ)、乌头碱(Ⅷ)、12-表-欧乌头碱(Ⅸ)、欧乌头碱(Ⅹ)和6-O-去甲基尼奥灵(Ⅺ)。结论二萜生物碱是伏毛铁棒锤药材的主要化学成分,其中Ⅱ,Ⅳ~Ⅶ和Ⅺ为首次从该植物中分离得到。
Abstract
OBJECTIVE To study the diterpene alkaloids from the roots of Aconitum flavum Hand.-Mazz. METHODS Diterpene alkaloids were isolated by silica gel column,and identified by physicochemical data and spectral methods.RESULTS Eleven diterpene alkaloids were isolated and identified as 3-deoxyaconitine(Ⅰ),3-deoxyaconine-8-linoleate(Ⅱ),3-acetylaconitine(Ⅲ),16,17-dihydro-12β,16β-epoxynapelline(Ⅳ),neoline(Ⅴ),songorine(Ⅵ),aconine-8-linoleate(Ⅶ),aconitine(Ⅷ),12-epi-napelline(Ⅸ),napelline(Ⅹ) and 6-O-demethylneoline(Ⅺ). CONCLUSION Diterpene alkaloids are the main chemical constituents of A.flavum,and compound Ⅱ,Ⅳ~Ⅶ and Ⅺ are found in this plant for the first time.
关键词
伏毛铁棒锤 /
毛茛科 /
二萜生物碱
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Key words
Aconitum flavum Hand. -Mazz /
Ranunculaceae /
diterpene alkaloid
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张帆;王兴明;彭树林;丁立生.
伏毛铁棒锤根部二萜生物碱的研究[J]. 中国药学杂志, 2006, 41(24): 1851-1853
ZHNG Fn;WNG Xing-ming;PENG Shu-lin;DING Li-sheng.
Study on Diterpene Alkaloids from the Roots of Aconitum flavum[J]. Chinese Pharmaceutical Journal, 2006, 41(24): 1851-1853
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参考文献
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脚注
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