OBJECTIVE To develop the formulation of self-microemulsifying drug delivery system for vinpocetine(VIN-SMEDDS). METHODS The optimum formulations of VIN-SMEDDS were screened by solubility experiments, compatibility tests and pseudo-ternary phase diagrams,with the time of formulating microemulsion, the consequence of visual examination and particle size as parameters. And the physic-chemical characters and dissolution in vitro of VIN-SMEDDS were also determined.RESULTS The optimum self-microemulsifying drug delivery system was composed of GTCC(55%), oil acid(5%),Cremophor EL(30%), Transcutol P(10%).The particle diameter was (40.16±5.58) nm, the time of self-microemulsifying was less than 1 min. The percent of accumulated dissolution of vinpocetine in SMEDDS in simulated intenstinal fluid was at 2 h up to 90.01%,which was 8.1 times as much as that of VIN raw powder(11.07%).CONCLUSION The formulation of VIN-SMEDDS preparation achieves the request of design. It can provide reference for the new dosage form.
LI Go;CHEN Ying;WNG Rui-hu.
Study on Self-Microemulsifying Drug Delivery System of Vinpocetine [J]. Chinese Pharmaceutical Journal, 2006, 41(23): 1795-1798
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