糖胺聚糖对肿瘤细胞生长因子及其介导的Ras/MAPK信号转导通路的调节机制

宫蔚;姬胜利;迟延青

中国药学杂志 ›› 2006, Vol. 41 ›› Issue (23) : 1767-1770.

中国药学杂志 ›› 2006, Vol. 41 ›› Issue (23) : 1767-1770.
综述

糖胺聚糖对肿瘤细胞生长因子及其介导的Ras/MAPK信号转导通路的调节机制

  • 宫蔚;姬胜利;迟延青
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摘要

目的介绍糖胺聚糖(GAGs)对肿瘤细胞生长因子及其介导的Ras/MAPK信号转导通路的影响,为进一步研究GAGs与肿瘤的关系及其生物学功能提供参考。方法对近年来有代表性的文献进行分析、归纳。结果肝素等GAGs对多种肿瘤生长因子及其信号转导通路均有重要的调节作用。结论进一步阐明肝素等GAGs作用于肿瘤细胞生长因子及信号转导通路的机制,对设计新型寡糖类靶向抗肿瘤药物有重要意义。

关键词

糖胺聚糖 / 肿瘤 / 生长因子 / 信号转导

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宫蔚;姬胜利;迟延青. 糖胺聚糖对肿瘤细胞生长因子及其介导的Ras/MAPK信号转导通路的调节机制[J]. 中国药学杂志, 2006, 41(23): 1767-1770

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