[1] FIRE A,XU S,MONTGOMERY M K,et al. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans[J] .Nature,1998,391(6669): 806-811.
[2] CAPLEN N J. Gene Therapy Progress and Prospects. Downregulating gene expression: the impact of RNA interference[J] .Gene Therapy,2004,11(16):1241-1248.
[3] MA P P,XUE S P,HAN D S. Principles and applications of RNA interfering technology[J] .Chin J Histochem Cytochem (中国组织化学与细胞化学杂志),2003,12(2): 201-207.
[4] SIDDHESH D,DAVID G,DIANE J.DNA-based therapeutics and DNA delivery systems: A comprehensive review[J] .The AAPS J,2005,7(1): E61-E77.
[5] DORSETT Y,TUSCHL T. siRNAs: applications in functional genomics and potential as therapeutics[J] .Nat Rev Drug Discov,2004,3(4): 318-329.
[6] RAY K M,PAUL A. RNA interference: from gene silencing to gene-specific therapeutics[J] .Pharmacology Therapeutics,2005,107(2): 222-239.
[7] RYTHER R C,FLYNT A S,Phillips J A,et al. siRNA therapeutics: big potential from small RNAs[J] .Gene Therapy,2005,12(1): 5-11.
[8] NOVINA C D,SHARP P A.The RNAi revolution[J] .Nature,2004,430(6996): 161-164.
[9] REN X,SONG Y G,CHEN X Q. Progress in research of RNAi[J] . World Clin J Digestol(世界华人消化杂志),2004,12(3): 748-750.
[10] BARIK S. Development of gene-specific double-stranded RNA drugs[J] .Ann Med,2004,36: 540-551.
[11] GONG H,LIU C M,LIU D P,et al. The role of small RNAs in human diseases: potential troublemaker and therapeutic tools[J] .Med Res Rev,2005,25(3): 361-381.
[12] SHLOMAI A,SHAUL Y. RNA interference--small RNAs effectively fight viral hepatitis[J] .Liver Int,2004,24(6): 526-531.
[13] BERKHOUT B. RNA interference as an antiviral approach: targeting HIV-1[J] .Curr Opin Mol Ther,2004,6(2): 141-145.
[14] SUN J. Progress in using RNA interference against HIV infection[J] . Clin Pharm J(中国药学杂志),2005,40(2): 84-86.
[15] KRONKE J,KITTLER R,BUCHHOLZ F,et al. Alternative approaches for efficient inhibition of hepatitis C virus RNA replication by small interfering RNAs[J] .J Virol,2004,78(7): 3436-3446.
[16] YUAN J,CHEUNG P K,ZHANG H M,et al. Inhibition of coxsackievirus B3 replication by small interfering RNAs requires perfect sequence match in the central region of the viral positive strand[J] .J Virol,2005,79(4): 2151-2159.
[17] ZHENG B J,GUAN Y,TANG Q,et al. Prophylactic and therapeutic effects of small interfering RNA targeting SARS-coronavirus[J] . Antivir Ther,2004,9(3): 365-374.
[18] MOHAPATRA J K,SANYAL A,HEMADRI D,et al.Evaluation of in vitro inhibitory potential of small interfering RNAs directed against various regions of foot-and-mouth disease virus genome[J] .Biochem Biophys Res Commun,2005,329(3): 1133-1138.
[19] KUMAR R,ADAMS B,OLDENBURG A,et al. Characterisation and expression of a PP1 serine/threonine protein phosphatase (PfPP1) from the malaria parasite,Plasmodium falciparum:demonstration of its essential role using RNA interference[J] .Malar J,2002,1(1):5.
[20] VAYSSIE L,VARGAS M,WEBER C,et al. Double-stranded RNA mediates homology-dependant gene silencing of gamma-tubulin in the human parasite Entamoeba histolytica[J] .Mol Biochem Parasitol,2004,138(1):21-28.
[21] YANG Z,CLOUD A,HUGHES D,et al. Stable inhibition of human thymidylate synthase expression following retroviral introduction of an siRNA gene[J] .Cancer Gene Ther,2006,13(1): 107-114.
[22] WANNENES F,CIAFRE S A,NIOLA F,et al. Vector-based RNA interference against vascular endothelial growth factor-A significantly limits vascularization and growth of prostate cancer in vivo[J] .Cancer Gene Ther,2005,12(12): 926-934.
[23] CHEN Z J,KREN B T,WONG P Y,et al. Sleeping beauty-mediated down-regulation of huntingtin expression by RNA interference[J] . Biochem Biophys Res Commun,2005,329(2): 646-652.
[24] XIA X G,ZHOU H,ZHOU S,et al. An RNAi strategy for treatment of amyotrophic lateral sclerosis caused by mutant Cu,Zn superoxide dismutase[J] .J Neurochem,2005,92(2): 362-367.
[25] MILLER T M,KASPAR B K,KOPS G J,et al. Virus-delivered small RNA silencing sustains strength in amyotrophic lateral sclerosis[J] .Ann Neurol,2005,57(5): 773-776.
[26] ZHANG X Q. The concept,character,and implication of gene therapy[J] .Nature Magazine(自然杂志),2003,25(3): 153-156.
[27] SOUTSCHEK J,AKINC A,BRAMLAGE B,et al. Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs[J] .Nature,2004,432(7014): 173-178.
[28] JOHN J A. Cholesterol connection in RNAi[J] .Nature,2004,432(7014): 155-156.
[29] CROMBIE C,FRASER A. Treating genetic disease through RNA interference[J] .Lancet,2005,365(9467): 1288-1290.
[30] GUO X H,HAN X X,ZHOU X Z.The gene delivery technology in gene therapy[J] .Letters Biotechnol(生物技术通讯),2003,14(3): 235-237.
[31] ELMEN J,THONBERG H,LJUNGBERG K,et al. Locked nucleic acid (LNA)mediated improvements in siRNA stability and functionality[J] .Nucleic Acids Res,2005,33(1):439-447.