OBJECTIVE To study the inclusion effects of β-CD and HP-β-CD on monobenzone.METHODS The content of monobenzone was determined by the UV chromatography method.The phase solubility method was used to study the intermolecular reaction between the host and guest agents, the soluble effects of 2CDs on monobenzone and thermodynamic profiles in the complexation.RESULTS All thermodynamic parameters of △G,△H and △S in the complexations gave negative values.The solubility and dissolution was improved when monobenzone complexed with HP-β-CD or β-CD,however the stability constant of monobenzone-β-CD was higher than that of monobenzone-HP-β-CD.CONCLUSION The 1∶1 molar ratio of inclusion complex of monobenzone with each CD is spontaneously formed under the experimental temperature.The solubility and dissolution of monobenzone complexed with HP-β-CD is higher than that of monobenzone complexed with β-CD.However,the stability constant of monobenzone-β-CD is higher than that of monobenzone-HP-β-CD.
WNG Lu-lu;ZHENG Wen-sheng.
Inclusion Effects of β-CD and HP-β-CD on Monobenzone [J]. Chinese Pharmaceutical Journal, 2006, 41(07): 529-531
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