OBJECTIVE To investigate the therapeutic effect of dipfluzine(Dip) on stroke in stroke prone spontaneously hypertensive rats(SHRSP).METHODS The SHRSP were used to study effects of Dip on stroke.The neurological deficits,body weight,life span,rate of platelet adhesiveness,brain coefficient and pathomorphological changes were measured after stroke was induced in SHRSP.RESULTS After the onset of stroke,the life span of the rats was prolonged,the score of neurological deficit,rate of platelet adhesiveness and brain coefficient were reduced markedly and the neuronal density in hippocampal CA1 region was increased by Dip.CONCLUSION Dip might have the therapeutic effect on stroke in SHRSP.
ZHNG Wei;CHEN Xue-yn;LI Hi-fng;MIO Qing-feng;ZHNG Yong-jin;WNG Yong-li.
Therapeutic Effect of Dipfluzine on Stroke in Stroke-Prone Spontaneously Hypertensive Rats [J]. Chinese Pharmaceutical Journal, 2006, 41(05): 351-353
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