目的：研究盐酸二甲双胍肠溶片与普通片的药动学和生物利用度。方法：受试者交叉口服单剂量（1000 mg）肠溶片与普通片，用反相高效液相色谱法测定血药浓度。结果：两种片剂的主要药动学参数分别为C_max（2.9±0.7）mg·L^-1和（2.6±0.6）mg·L^-1，T_max为（2.6±0.4）和（2.3±0.5）h ，T_1/2Ka为（0.87±0.26）h和（0.81±0.23）h，T_1/2Ke为（1.6±0.4）h和（1.9±0.6）h，AUC为（12.2±1.1）mg·L^-1·h^-1和（11.9±1.2）mg·L^-1·h^-1。肠溶片相对于普通片的生物利用度F为(103.0±12.0)%。结论：两种剂型的各药动学参数之间差异均无显著性(P>0.05)，经双向单侧t检验，两制剂具有生物等效性。

OBJECTIVE The pharmacokinetics and bioavailability of metformin hydrochloride enteric dissolve tablets were compared with stomach dissolving tablets.METHODS Plasma levels of metformin were detected by RP-HPLC method.RESULTS The parameters of the two formulations for metformin: Cmax of enteric and stomach dissolving tablets were (2.9±0.7) mg·L^-1 and (2.6±0.6)mg·L^-1，T_max(2.6±0.4) h and(2.3±0.5)h；T_1/2Ka(0.87±0.26) h and (0.81±0.23) h；T_1/2Ke（1.6±0.4）and（1.9±0.6）h, AUC（12.2±1.1）and（11.9±1.2） mg·L^-1·h^-1 respectively.The relative bioavailability of enteric dissolving tablets was (103.0±12.0)%.CONCLUSIONS There was no significant difference in pharmacokinetic parameters. It was demonstrated that the two preparations were bioequivalent by one two-sidest tests.