香荷药条的体外释放药动学

邓远辉;杨柳;冯怡;董玉珍;

中国药学杂志 ›› 2002, Vol. 22 ›› Issue (07) : 390-391.

中国药学杂志 ›› 2002, Vol. 22 ›› Issue (07) : 390-391.
研究论文

香荷药条的体外释放药动学

  • 邓远辉;杨柳;冯怡;董玉珍;
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Study on the releasing dynamics in vitro of Xianghe medicinal strip

  • DENG Yuan-Hui;YANG Liu;FENG Yi; et al
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摘要

目的:研究香荷药条的体外释药特性。方法:采用反相高效液相色谱法测定药条中的指标成分含量,以pH4.5乳酸溶液为介质,用磁力搅拌法研究药条中药物的释放情况。结果:香荷药条的体外释放行为符合一级动力学方程。2 h及12 h的累积释放百分率分别为61.9%和94.2%。结论:香荷药条具有双相释放药物的特性。

Abstract

OBJECTIVE To study the drug-releasing characteristics in vitro of Xianghe medicinal strip. METHODS The content of the index composition was determined by HPLC. Magnetic stirring method was used to study the releasing rule with releasing medium of lactic acid solution (pH 4.5). RESULTS Releasing in vitro of the strip conforms to first order kinetics equation. The accumulative releasing percentage of 2 hours and 12 hours was 61.9% and 94.2%, respectively.CONCLUSIONS The releasing characteristics of Xianghe medicinal strip can be described by two-phase dynamic model.

关键词

香荷药条 / 体外溶出 / 释药机制

Key words

Xianghe medicina strip / dissolution in vitro / drug-releasing mechanism

引用本文

导出引用
邓远辉;杨柳;冯怡;董玉珍;. 香荷药条的体外释放药动学[J]. 中国药学杂志, 2002, 22(07): 390-391
DENG Yun-Hui;YNG Liu;FENG Yi;et l. Study on the releasing dynamics in vitro of Xianghe medicinal strip[J]. Chinese Pharmaceutical Journal, 2002, 22(07): 390-391

参考文献

[1] 杨柳,邓远辉,董玉珍,等.香荷药条的制备工艺研究[J].中草药.1999,30(5):344. [2] 王本祥. 现代中药药理学[M].第1版.天津:天津科学技术出版社,1997.302. [3] 杨柳,邓远辉,董玉珍,等.HPLC测定香荷药条中小檗碱及巴马亭的含量[J].中国现代应用药学杂志,2001,18(5):382.

基金

广东省重点科技攻关项目(9622007-03)

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