目的 测定葛根黄酮载药系统表征，据此检测乙基纤维素/聚乙二醇(EC/PEG)混合载体、PEG单一载体用固体分散技术，对葛根黄酮的分散作用。方法 用差示量热扫描，X衍射分析、红外光谱及电子扫描显微镜照相等手段。结果 用固体分散技术，使葛根黄酮以均匀的状态分散在载药系统中，EC/PEG葛根黄酮固体分散体中，EC/PEG与葛根黄酮分子间相互作用，形成一种新的物相；PEG葛根黄酮固体分散体中，借分子中的·OH形成更多的氢键。EC/PEG葛根黄酮固体分散体释放12 h后与释放前的形态显微图比较，相态变大变宽，且疏松。结论 固体分散技术对葛根黄酮有很好的分散作用。药物以分子尺度分散在载体中，PEG促进药物的释放，EC/PEG具有溶胀的作用。通过分析，EC/PEG葛根黄酮固体分散体为一理想的释药体系，先突释，后按零级动力学释药；PEG葛根黄酮固体分散体为一速释体系，上述分析手段为此提供了科学依据。

OBJECTIVE To determine the characteristics of RP isoflavones in differens drug carrier system,including EC/PEG mixture carrier and PEG single carrier by solid dispersion technique.METHODS DSC,X-ray diffraction,IR-spectra and SEM were used.RESULTS By using solid dispersion technique,RP isoflavones was homogeneously dispersed in the drug carrier system.EC/PEG RP isoflavones solid dispersion formed a new type of material phase because of interaction between EC/PEG and RP isoflavones molecules.The PEG RP isoflavones solid dispersions formed more hydro-keys resulted by -OH in the molecules.After releasing 12 h,the EC/PEG RP isoflavones solid dispersion became much bigger,wider and soft than the material before releasing.CONCLUSION RP isoflavones was dispersed in molecular size in the carrier.PEG was the hole-making agent improving the permeability to EC-membrane,and EC had the function of dissolution and inflation.It demonstrated that EC/PEG RP isoflavones solid dispersion was an ideal drug release system,which released fast at initial and then following zero-order mechanism;PEG RP isoflavones solid dispersion was a fast release system.