HIV-1整合酶抑制剂的研究进展

郭志敏;陈鸿珊;

中国药学杂志 ›› 2001, Vol. 36 ›› Issue (11) : 721-723.

中国药学杂志 ›› 2001, Vol. 36 ›› Issue (11) : 721-723.
综述

HIV-1整合酶抑制剂的研究进展

  • 郭志敏;陈鸿珊;
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摘要

目的 介绍HIV治疗的新靶点——整合酶抑制剂,为寻找新的有效的抗艾滋病药物提供理论依据。方法 根据近年来国外文献进行综述。结果与结论 HIV复制过程中还有另一个重要的酶——整合酶,使病毒基因组整合于宿主细胞染色体,病毒在体内长期潜伏。整合酶是HIV自身特有的酶,也是一个抗HIV药物设计的理想靶点。目前整合酶抑制剂有DNA结合剂和拓扑异构酶抑制剂;核苷类;肽类;多羟基化芳香族化合物四大类。

关键词

HIV-1 / 整合酶 / 抑制剂

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郭志敏;陈鸿珊;. HIV-1整合酶抑制剂的研究进展[J]. 中国药学杂志, 2001, 36(11): 721-723

参考文献

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