蛋白质和多肽类药物的聚乙二醇结合物——一种新型给药系统

印春华;张敏

中国药学杂志 ›› 2001, Vol. 36 ›› Issue (05) : 292-296.

中国药学杂志 ›› 2001, Vol. 36 ›› Issue (05) : 292-296.
综述

蛋白质和多肽类药物的聚乙二醇结合物——一种新型给药系统

  • 印春华;张敏
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摘要

目的介绍蛋白质和多肽类药物的聚乙二醇结合物研究的最新进展。方法根据近几年的文献资料对蛋白质和多肽类药物的聚乙二醇修饰方面的研究进行综述。结果聚乙二醇修饰的蛋白质和多肽类药物可增加药物的溶解度和稳定性,减弱或消除免疫原性、抗原性和毒性,改善药物的体内药动学性质,增加药物的体内半衰期,增加治疗指数等。结论蛋白质类和多肽类药物的聚乙二醇结合物是很有前途的蛋白质和多肽类药物的新型给药系统。

关键词

蛋白质类药物 / 多肽类药物 / 聚乙二醇结合物

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导出引用
印春华;张敏. 蛋白质和多肽类药物的聚乙二醇结合物——一种新型给药系统[J]. 中国药学杂志, 2001, 36(05): 292-296

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