目的 研究国产依普拉封片（ipriflavone）防治绝经后骨质疏松症疗效的生化学监测及疗效机制。方法 绝经后骨质疏松症54例，其中治疗组30例服用国产依普拉封片合用钙尔奇-D治疗6个月，对照组24例单独服用钙尔奇-D6个月，检测两组用药前后骨代谢生化指标。结果 治疗组结果表明骨吸收的指标：甲状旁腺素（PTH）、抗酒石酸盐酸性磷酸酶（TRAP）、尿胶原交联/肌酐比值（Crosslaps/Cr）均明显降低；骨形成/骨转换的指标:碱性磷酸酶（ALP）、骨钙素（BGP）、I型前胶原羧基端前肽（PICP）亦下降；骨重建刺激因子:胰岛素样生长因子-1(IGF-1)显著升高。对照组，TRAP也有轻度下降。结论依普拉封片能明显的影响骨代谢：抑制骨吸收,降低骨转换, 减少骨量丢失,治疗1个月即可出现作用；刺激骨重建，增加骨密度，能够有效地防治绝经后骨质疏松症。生化指标可用于疗效的早期监测。

OBJECTIVE To monitor the change of biochemistry in patients with postmenopausal osteoporosis after intaking ipriflavone and discuss its action mechanism. METHODS 54 patients with post-menopause osteoporosis were divided into 2 groups:30 patients were administrated with ipriflavone and Caltrate-D for 6 months.24 patients in control group were only given Caltrate-D for 6 months.The bone biochemical indexes were monitored before and after the treatment. RESULTS PTH, TRAP and Crosslaps/Cr, the indexes of bone absorption, decreased markedly; ALP, BGP and PICP, the indexes of bone formation/turnover, decreased markedly.IGF-1, strong stimulator of bone rebuild, significantly increased.In the control group，Ca2+in blood and TRAP lightly decreased. CONCLUSION The results indicated ipriflavone decreased the bone absorption and bone turnover rate, prevented bone loss.The efficacy appeared in 1st month after administration;stimulating bone rebuild,and raise BMD.It is effective in preventing and treating postmenopausal osteoporosis.Biochemistry index can be used to monitor the effect of treatment early.