毛裂蜂斗菜化学成分的研究

程捷恺

中国药学杂志 ›› 1999, Vol. 34 ›› Issue (11) : 734-736.

中国药学杂志 ›› 1999, Vol. 34 ›› Issue (11) : 734-736.
中药及天然药物

毛裂蜂斗菜化学成分的研究

  • 程捷恺
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Study on struoture of compounds isolated from Petasites tricholobus France

  • Cheng Jiekai
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摘要

目的:对毛裂蜂斗菜的化学成分进行结构研究?方法:通过多次柱层析和重结晶分离纯化,并运用现代光谱技术进行结构鉴定?结果:分离鉴定了6个化合物,它们分别是羽扇豆醇,Bakkenolide-B,Bakkenolide-E Bakkenolide-D,三十二碳酸,β-谷甾醇?结论:上述6种化合物均为首次从毛裂蜂斗菜中分离得到?Bakkenolide-D 经初步试验,具有抗放射性。

Abstract

OBJECTIVE:To study the structure of the compounds isolated from Petasites tricholobus France.METHODS:To isolated and purify the compounds by means of multi-column chromatograpoy and recrystallzation,and using analyses of modern technique of spectra.RESULTS:Six compounds were obtained.They were lupeol,bakkenolide D,Baskkenolide E,bakkenolide B,dotriacontanoic acid and β-sitosterol.CONCLUSION:These compounds were isolated for the first time from Petasites tricholobus France

关键词

毛裂蜂斗菜 / 倍半萜 / Bakkenolide

Key words

Petasites tricholobus France / Sesquiterpene / Bakkenolide

引用本文

导出引用
程捷恺. 毛裂蜂斗菜化学成分的研究[J]. 中国药学杂志, 1999, 34(11): 734-736
Cheng Jieki. Study on struoture of compounds isolated from Petasites tricholobus France[J]. Chinese Pharmaceutical Journal, 1999, 34(11): 734-736

参考文献

1 江苏新医学院编.中药大辞典.上海:上海科学技术出版社,1997:2483. 2 丛浦珠编.质谱学在天然有机化学中的应用.北京:北京科学技术出版社,1982:711. 3 Patra A,Mitra AK,Chatterjee TK,et al.Carbon-13 NRA spectra of some novel migrated hopanes and 21α-H hopanes.Org Magn Resomance,1981,17(2):148. 4 Abe N,onoda R,Shirahata K,et al.The structures of bakkenolides-B,-C,and -D as determined by the use of a unc lear overhauser effect.Tetrahedron lett,1968,16:1993. 5 Naya K,Hayashi M,Takagi I,et al.The structural elucidation of sesquiterpene Lactones from petasite japonicus Maxim.Bull Chem Soc Jap,1972,45(12):3673. 6 Shirahata K,Kato T,Y.Mass speacra of bakkenolides and their derivatives.Tetrahedrom,1969,25(19):4671.

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