目的:阐明手性药物相互作用的概念及其研究的临床意义。方法:综述近几年手性药物相互作用的研究状况和研究方法。结果:一些消旋体药物的对映体与对映体、对映体与其它并用药物之间在药效学或药动学上发生了相互作用。其中有些手性相互作用在临床上被视为是有益的,有些则引起药物不良反应。遗传多态性和年龄相关性在手性相互作用中也有发生。结论:手性药物相互作用的研究能更深入地理解或积极地预期一些药物相互作用,为临床合理用药提供依据。
关键词
对映体 /
相互作用 /
手性药物 /
立体选择性
{{custom_keyword}} /
{{custom_sec.title}}
{{custom_sec.title}}
{{custom_sec.content}}
参考文献
1 Zheng W,Stoltefuss J,Goldmann S,et al.Pharmacologic and radiolig and binding studies of 1,4-dihydropyridines in rat cardiac and vascular preparations:stereoselectivity and voltage-dependence of antagonist and activator interactions.Mol Pharmacol,1992,41: 535.
2 Tobert JA,Cirillo VJ,Hitzenberger G,el al.Enhancement of urieosuric properties of indacrinone bY manipulation of the enantiomer ratio.Clin Pharmacol Ther,1981,29:344.
3 Itoh T,Maruyama J,Tsuda Y,et al.Stereoselective pharmacokinetics of ibuprofen in rats:effects of enantiomer-enantiomer interaction in plasma protein binding.Chirality,1997,9(4):354.
4 Itoh T,Nakashima K,Tsuda Y,et al.Stereoselective binding of carbencillin epimers tO human serum albumin.Chirality,1996,8 (2):201.
5 Bode W,Toet AE,Stolker AA,et al.Toxicokinetics of a single intravenous dose of Rac-propranolol versus optically pure propranolol in the rat.Chirality,1995,7(8):626.
6 Takahashi H,Ogata H,Seki Y,et al.Binding interaction between enantiomers of disopyramide and mono-N-dealkyldisopyamide on plasma protein.Drug Metab Dispos,1991,19:554.
7 Kroemer HK,Fromn MF,Buxh K,et al.An enantiomer-enantiomer interaction of (S)-and (R)-propafenone modifies the effect of racemic drug therapy.Circulation,1994,89:2396.
8 Kroemer HK,Fischer C,Meese CO,et al.Enantiomer/enantiomer interaction of (S)-and (R)-propafenone for CYP2D6 catalyzed 5-hydroxylation:in vitro evaluation of the mechanism.Mole Pharmacol,1991,40:135.
9 Torchin CD,McNeiUy PJ,Kapetanovic IM,et a1.Stereoselective metabolism of a new anticonvulsant drug candidate,losigamone,by human live microsomes.Drug Metab Dispos,1996,24(9):1002.
10 Mast V,Fischer C,Mikus G,et al.Use of pseudoracemic nitrendipine to elucidate the metabolicsteps for stereoselective diswsition of nitrendipine enantiomers.Br Clin Pharmacol,1992,33:51.
11 Kunze KL,Eddy AC,Gibaldi M,et a1.Metabolic enantiomeric interactions:the inhibition of human (S)-warfarin-7-hydroxylase by (R)-warfarin.Chirality,1991,3:24.
12 Choonara IA,Cholorton S,Haynes BP,et al.Stereoselective interaction between the R-enantiomer of warfarin and cimetidine.Br J Clin Pharmacol,1986,21:271.
13 Sweeny DJ,Nellans HN.Enantiomeric activation of glucuronidation in drug hepatic microsomes.J Biol Chem,1992,267(19):13171.
14 Carr RA,Pasutto FM,Foster RT,et al.Stereosepecific evaluation of sotalol pharmacokinetics in a rat model:evidence suggesting an enantiomeric interaction.Biopharm Drug Dispos,1994,15(2):109.
15 He J,Shibukama A,Tokunaga S,et al.Protein binding high performance frontal analysis of (R)-and (S)-warfarin on HSA with and without phenybutazone.J Pharm Sci,1997,86(1):120.
16 Fitos I,Visy J,Simonyi M,et al.Stereoselective allosteric binding interaction on human serum albumin between ibuprofen and lorazepam acetate.Chirality,1999,11(2):115.
17 Scheuerer S,Willian KM,Brugger R,et al.Effect of clofibrate on the chiral disposition of ibuprofen in rats.J Pharmacol Exp Ther, 1998,284(3):1132.
18 Awni WM,Hussein Z,Granneman GR,et al.Pharmacodynamic and stereoselectire pharmacokinetic interaction between zilcuton and warfarin in humans.Clin Pharmacol,1995,29(Suppl.2):67.
19 Heimark LD,Wienkers L,Kunze K,et al.The mechanism of the interaction between amiodarone and warfarin in humans.Clin Pharmacol Ther,1992,51:398.
20 Hunn BA,Bottorf MB,Herring LV,et al.Effects of cacium blockers on the pharmacokinetics of propranolol stereoisomers.Clin Pharmacol Ther,1990,47:584.
21 Vercrusse I,Belpaire F,Wynant P,et al.Enantioselective inhibitory effect of nicardipine on the hepatic clearance of propranolol in man.Chirality,1994,6(1):5.
22 Kima M,Shen DD,Eddy AC,et al.Inhibition of the enantioselective oxidation metabolism of metoprolol by verapamil in human live microsomes.Drug Metab Dispos,1993,21(2):309.
23 Mikus G,Eichelbaum M,Fischer C,et al.Interaction of verapamil and cimetidine:stereochemical aspecls of drug disposition,metabolism and drug action.J Pharmacol Exp Ther,1990,253(3):1042.
24 Somogyi AA,Bochner F,Sallustio BC,et al.Stereoselective inhibition of pindolol renal clearance by cimetidine in humans.Clin Pharmacol Ther,1992.51:379.
25 Laethem ME,Belpaire FM,Wijnant P,et al.Effect of probenecid on the enantioselective pharmacokinetics of oxprenolol and its glucuronides in the rabbit.Pharm Res,1995,12(12):1964.
26 Bonnabry P,Desmules J,Rudaz S,et al.Stereoselective interaction between piroxicam and acenocoumarol.Br J Clin Pharmcol,1996,41(6):525.
27 Zhou HH,Anthony LB,Wood AJJ,et al.Induction of polymophic 4-hydroxylation of S-mephenytoin by rifampicin.Br J Clin Pkarmacol,1990.30:471.
28 Smith DA,Chandler MHH,Shedlofsky SI,et al.Age-dependent stereoselective increase in the oral clearance of hexobasrbitone isomers caused by rifampicin.Br J Clin Pharmacol,1991,32:735.
29 丁永生,朱晓峰,林炳承.人血清白蛋白与手性药物相互作用的毛细管电泳研究Ⅱ:药物对映体竞争结合参数的测定.色谱,1999,17(2):138.
{{custom_fnGroup.title_cn}}
脚注
{{custom_fn.content}}
基金
国家自然科学基金(39770868)资助项目
{{custom_fund}}