目的:观察3种亲疏水性不同的新型药物辅料聚天冬酰胺衍生物PHPA,PHPPA-3∶7和PHPPA-7∶3在动物体内的形态变化和降解过程。方法:采用组织切片和高效液相凝胶色谱法,对小鼠的埋植部位、肝脏和肾脏进行观察和检测。结果:发现3种材料在埋植部位均出现了从棕黑色固态到黄色胶状、再到棕色或黑色细小颗粒的形态变化,且其均能降解形成大小不同的分子片段。其中水溶性较强的PHPA较早出现细小颗料和降解高峰。三者均可被吸收到达肝肾组织。结论:3种材料在小鼠皮下均可溶胀、降解,水溶性强的材料较早出现降解。
Abstract
OBJECTIVE:To observe the degradation process of three new pharmaceutical necessities of PHPA,PHPPA-3∶7 and PHPPA-7∶3 in vivo.METHODS:The tissue section method and GPC were used to test the change in the planting prat,liver and kidney.RESULTS:We found that the shape of the three materials changed from brown solidto yellow gel,brown or black tiny particles,then degraded into different molecule fragments.The PHPA with more hydrosoluble property,presented the ting particles and high degradation pointearly.After absorbed,the degradation products of three materials got to liver and kidney.CONCLUSION:The three kinds of material may be resolved and degraded in the hypodermis of the mice.The more hydrosolube PHPA degradatede arlier.
关键词
聚-(3-羟丙基)-DL-天冬酰胺 /
皮下埋植 /
降解
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Key words
poly-(3-hydroxyethy)-DL-asparamid /
implanting /
degradation
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参考文献
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脚注
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基金
国家自然科学基金资助项目,第39570219号
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