摘要
目的:研究吸入剂体外模拟实验方法,进行有效药物量的测定。方法:采用自制双层液体碰撞器进行测定,第一级接受液为7ml,第二级(作用部位)接受液为30ml,抽吸速度为60L·min-1。测定结果与国外文献进行比较。结果:测定结果与国外文献一致,吸入剂有效部位药物量与剂型、品种及接受液种类有关。结论:自制双层液体碰撞器可用于吸入剂的质量监控。
Abstract
OBJECTIVE:To study on method of inhalation simulation test in vitro.The effective dose of inhalation was deter mined.METHOD:The imitated twin-stage liq wuid impinger was used to dtermine the effective dose of inhalation.There was 7ml receiving liquid in stageⅠ,and 30 ml in stageⅡ (simulated action position).The aspirated speed was 60L·min-1.The test results were compared with that reported.RESULTS:There sults were corresponded with the foreign reports.The effective dose of inhalation was related to the dosage form,active ingredient properties and the receiving liquid kings.CONCLUSION:The imitated twin-stage liquid impinger could be used to control the quality of inhalation product.
关键词
吸入剂 /
有效部位药物量 /
双层液休碰撞器
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Key words
inhalation /
the effective dose /
twin-stage liquid impinger
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金方;施丽西;陆敏;谢保源.
吸入剂有效部位药物沉积量试验方法的研究[J]. 中国药学杂志, 1999, 34(10): 672-674
Jin Fng.
Studies on test method of the effective deposition for inhalation[J]. Chinese Pharmaceutical Journal, 1999, 34(10): 672-674
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参考文献
1 Hallworth GW.The twin impinger:a simple device for assessing the delivery of drtlgs from meterde dose pressurized aerosol inhalers.J Pharmacol,1987,39:966.
2 Martin GP,Bell AE,Marriott C.An in vitro method for assessing particle deposition from metered pressurised aerosols and dry powder inhalers.Int J Pharm,1988,44(1):57.
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脚注
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