国产PVPP用作片剂崩解剂的初步评价

郭圣荣

中国药学杂志 ›› 1999, Vol. 34 ›› Issue (06) : 384-386.

中国药学杂志 ›› 1999, Vol. 34 ›› Issue (06) : 384-386.
药剂

国产PVPP用作片剂崩解剂的初步评价

  • 郭圣荣
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Preliminary estimation of domestic PVPP as a tablet disintegrant

  • Guo Shengrong
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摘要

目的:对国产交联聚维酮(PVPP)用作片剂崩解剂初步评价?方法:参照美国药典中交聚集维酮(crospovidone)的有关规格,评估PVPP的质量;测定国产PVPP的松密度、流动性、溶胀性、崩解性并与德国产的Kolindon CL比较?结果:国产PVPP基本符合美国药典有关规定,具有和Kolindon CL相似的性能?结论:国产PVPP可用作片剂崩解剂?

Abstract

OBJECTIVE: To estimate domestic PVPP as a tablet disintegrant. METHODS: To evaluate the quality of domestic PVPP by reference to the specifications of crospovidone in USP,and to study the bulk dinsity,fluidity,swelling and the effects of them on disintegrantion of tablets and compare with Kokkindon CL. RESULTS: Domestic PVPP basically conformed to the specifications in USP,its swelling and disintegrating properties were to Kollindon CL. CONCLUSION :The domestic PVPP can be used as one of tablet disintegrants.

关键词

交联PVP / 崩解剂 / 溶胀性

Key words

crospovidone / disintegrant / swelling characteristics

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导出引用
郭圣荣. 国产PVPP用作片剂崩解剂的初步评价[J]. 中国药学杂志, 1999, 34(06): 384-386
Guo Shengrong. Preliminary estimation of domestic PVPP as a tablet disintegrant[J]. Chinese Pharmaceutical Journal, 1999, 34(06): 384-386

参考文献

1 Sheikh SM.Effect of crospovidone on the physical properties of acetaminophen tablets.Drug Dev Pharm,1995,21(15):1807. 2 Gordon MS.Effect of the mode of super disintegrant incorporation on dissolution in wet granulated tablets.J Pharm Sci,1993,82(2):220. 3 美国药典23版.1995:2239.

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