盐酸丙哌维林片稳定性及溶出度研究

刘玉玲;王净;夏学军;陶忠华;

中国药学杂志 ›› 1997, Vol. 32 ›› Issue (04) : 229-231.

中国药学杂志 ›› 1997, Vol. 32 ›› Issue (04) : 229-231.
药品检验

盐酸丙哌维林片稳定性及溶出度研究

  • 刘玉玲;王净;夏学军;陶忠华;
作者信息 +

Stability and dissolution study of propiverine hydrochloride tablets

  • Liu Yuling
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摘要

目的:对盐酸丙哌维林片剂的稳定性和溶出度进行系统研究。方法:采用高效液相色语-紫外检测法为测定影响因素试验、加速试验及室温留样条件下的稳定性和溶出度。结果:在各种考察条件下,样品的外观、含量、有关物 质及溶出度均未发生明显变化,45min时溶出度在85%以上。结论:盐酸丙哌维林片剂质量稳定,并具有较好的溶出性能。

Abstract

OBJECTIVE:To investigate the stability and dissolution of propiverine hydrochloride tablets systematically.METHODS: HPLGUV was used to determine the stability and dissolution of the samples to be laid in the condition of severe test, accelerated test and long-term storage test. RESULTS:Outward appearance, content, related substance and dissolution of the samples were not changed, and the dissolution rate was more than 85% in 45 min. CONCLUSION:The results show that propiverine hydrochloride tablets have good stability and dissolution.

关键词

盐酸丙哌维林 / 高效液相色谱 / 稳定性 / 溶出度

Key words

propiverine hydrochloride / HPLC / stability / dissolution

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导出引用
刘玉玲;王净;夏学军;陶忠华;. 盐酸丙哌维林片稳定性及溶出度研究[J]. 中国药学杂志, 1997, 32(04): 229-231
Liu Yuling. Stability and dissolution study of propiverine hydrochloride tablets[J]. Chinese Pharmaceutical Journal, 1997, 32(04): 229-231

参考文献

1 横山修,宫崎公臣,石田武之,等.频尿,尿失禁症例に对する盐酸プロピベリンの使用经验.泌尿纪要,1980,36:517. 2 大友英一,丸山腾一,小林逸郎,等.神经疾患に伴ろ排尿障害に对する盐酸プロピベリン(p-4)の临床评价.药理と治疗,1990,18(4):367. 3 中国药典1995年版.二部.1995:附录66.

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