摘要
目的:对盐酸丙哌维林片剂的稳定性和溶出度进行系统研究。方法:采用高效液相色语-紫外检测法为测定影响因素试验、加速试验及室温留样条件下的稳定性和溶出度。结果:在各种考察条件下,样品的外观、含量、有关物
质及溶出度均未发生明显变化,45min时溶出度在85%以上。结论:盐酸丙哌维林片剂质量稳定,并具有较好的溶出性能。
Abstract
OBJECTIVE:To investigate the stability and dissolution of propiverine hydrochloride tablets systematically.METHODS: HPLGUV was used to determine the stability and dissolution of the samples to be laid in the condition of severe test, accelerated test and long-term storage test. RESULTS:Outward appearance, content, related substance and
dissolution of the samples were not changed, and the dissolution rate was more than 85% in 45 min. CONCLUSION:The results show that propiverine hydrochloride tablets have good stability and dissolution.
关键词
盐酸丙哌维林 /
高效液相色谱 /
稳定性 /
溶出度
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Key words
propiverine hydrochloride /
HPLC /
stability /
dissolution
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刘玉玲;王净;夏学军;陶忠华;.
盐酸丙哌维林片稳定性及溶出度研究[J]. 中国药学杂志, 1997, 32(04): 229-231
Liu Yuling.
Stability and dissolution study of propiverine hydrochloride tablets[J]. Chinese Pharmaceutical Journal, 1997, 32(04): 229-231
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参考文献
1 横山修,宫崎公臣,石田武之,等.频尿,尿失禁症例に对する盐酸プロピベリンの使用经验.泌尿纪要,1980,36:517.
2 大友英一,丸山腾一,小林逸郎,等.神经疾患に伴ろ排尿障害に对する盐酸プロピベリン(p-4)の临床评价.药理と治疗,1990,18(4):367.
3 中国药典1995年版.二部.1995:附录66.
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脚注
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