法莫替丁缓释片的制备工艺及其体外释放特性的研究

曾环想;潘卫三;陈济民;庄殿友;吴涛;王涛;

中国药学杂志 ›› 1997, Vol. 32 ›› Issue (04) : 213-216.

中国药学杂志
中国药学杂志 ›› 1997, Vol. 32 ›› Issue (04) : 213-216.
药剂

法莫替丁缓释片的制备工艺及其体外释放特性的研究

  • 曾环想；潘卫三；陈济民；庄殿友；吴涛；王涛；
作者信息 +

Preparation and release of sustained-release famotidine tablet

  • Zeng Huanxiang
Author information +
文章历史 +

摘要

目的:制备法莫替丁缓释片剂，并评价其释放特性。方法:用正交试验设计对片剂的处方、工艺进行筛选与优化，制备法莫替丁缓释片剂，浏定其释放特性。结果:以优选的处方、工艺所制备的片剂，体外释药性能良好，符 合Higuchi模型，持续释药达12 h以上。结论:该片剂处方合理，工艺简单，适合于工业化生产，可为消化性清疡病的临床防治提供一个新剂型。

Abstract

OBJECTIVE: To prepare sustained-release famotidine tablet and evaluate its drug release property.METHODS: The optimal formulation and technology of the tablet were found with orthogonal experiment design.RESULTS: The release rate of the prepared tablet conformed to Higuchi equation and the drug was sustained released in vitro over 12 h. CONCLUSION: The tablet will play an important part in prevention and treatment of peptic ulcer as a result of its reasonable formulation and simple technology.

关键词

法莫替丁 / 缓释片剂 / 正交设计 / 制备 / 释放特性

Key words

famotidine / sustained-release tablet / orthogonal design / preparation / release property

引用本文

EndNote

Ris (Procite)

Bibtex

导出引用
曾环想;潘卫三;陈济民;庄殿友;吴涛;王涛;. 法莫替丁缓释片的制备工艺及其体外释放特性的研究[J]. 中国药学杂志, 1997, 32(04): 213-216
Zeng Hunxing. Preparation and release of sustained-release famotidine tablet[J]. Chinese Pharmaceutical Journal, 1997, 32(04): 213-216

参考文献

1 Campoli-Richards DM, Clissold SP.Famotidine:pharmacodynamic and pharmacokinetic properties and a preliminary reviev，of its therapeutic use in peptic ulcer disease and Zollinger-Ellison syndrome. Drug, 1986, 32: 197. 2 Langtry HD, Grant SM, Goa KL. Famotidine: An updated review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in peptic ulcer disease and other allied diseases. Drug, 1989, 38:551. 3 Amsden GW, Goss TF, Harrison NJ, et al.Pharmacodynamics of bolus famotidine versus infused cimetidine, ranitidine, and famotidine. J Clin Pharmacol,1994, 34(12):1191. 4 陶剑虹.杭溃疡新药——法莫替丁.新药与治疗。1988,(2):17. 5 Mohammad SS, Naji MN, Mohammad AH, et al .Kinetics of the acid-catalyzed hydrolysis of famotidine.Int J Pharm，1989. 54.65.6 Junnarkar GH, Starchansky S, Isothermal and onisothermal decomposition of famotidine in aquesous solution. Pharm Res, 1995,12(4):599. 7 李惠明，宣坚钢.法莫替丁片的紫外分光光度测定法.中国医药工业杂志，1993,24(7):319.

Accesses

Citation

Detail
段落导航
相关文章

/

〈 〉