摘要
用络合滴定法对国内10个厂家、国外2个厂家共27批不同类型的钙片、国产1种冲剂和l
种胶囊剂在水和0.1 mol/L盐酸介质进行了体外溶出试验。发现在酸性介质中30min的溶出速率和
溶出量皆大于水介质中45min的溶出。葡萄糖酸钙、乳酸钙和碳酸钙片溶出基本符合中国药药1990 年
版或美国药典ⅩⅩⅡ版要求，多数活性钙制剂的溶出可达80%以上，但有的咀嚼片和胶囊剂溶出低于55%
。口服补钙剂广泛用于治疗骨质疏松症，钙的溶出直接影响其生物利用度，现市售品种繁多，建议以钙含量的高低和
溶出度来合理选用钙制剂
Abstract
The dissolution of calcium preparations in water and 0. 1 mol/L HC1 medium was determined by complexometric titration.The results showed that the dissolution of tablets calcium gluconate.lactate and carbonate were in consistentr with regulations of ChP 1990 or USP XXⅢ,but the dissolution of some chewing tablets, capsule were lower than 55%.
关键词
补钙剂 /
溶出度
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Key words
calcium supplements /
dissolution
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梅丹;李大魁;庞国辉.
几种口服钙制剂的体外溶出度考察[J]. 中国药学杂志, 1995, 30(S1): 51-54
Mei Dn;Li Dkui;Png Gnohui.
Dissolution of calcium supplements[J]. Chinese Pharmaceutical Journal, 1995, 30(S1): 51-54
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参考文献
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5 Michael JB,William ED，Lenoard W,et al. In Vitro dissolu- tion of calcium carbonate preparations. Calcif Tissue Int，1991，49，308.
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7 Sheikh MS，Fordtran JS. Calcium bioavailability from two calcium carbonate preparations. N Engl J Med，1990，323 ：921.
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脚注
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