采用溶剂法制备硝酸咪康唑一聚乙烯吡咯烷酮（MCZ-PVP）共沉淀物，并用正交实验对共沉 淀物形成条件进行优选．结果表明：MCZ及PVP投料量比为l：12，在甲醇溶液中反应15 min，所形成 共沉淀物中MCZ溶解度为原纯MCZ的6.2倍。1：12共沉淀物经X-射线衍射图谱表明，MCZ的晶型 受到完全抑制，以无定型物分散于PVP骨架结构中．

The coprecipitates of miconazole nitrate (MCZ) with polyvinylpyrrolidone(PVP) are prepared by solvent method. Orthogonal experimental design was used in the synthesis of MCZ-PVP complex for optimization of the reactive conditions. The study showed that MCZ and PVP(1:12 ) were dissolved respectively in methylalco-hol. and mixed and heated for 15 minutes ,the coprecipitatc formed. The solubility of MCZ in coprecipitate was about 6. 2 times higher than the pure MCZ. X-ray differaction spectrum of 1:12 coprecipitate showed no crystalline structure of MCZ. MCZ was dispersed molecularly in the carrier of PVP.