通过正交试验设计筛选与优化了硫酸沙丁胺醇渗透泵型片剂的处方为硫酸沙丁醇9. 6 mg／片，高渗物质110 mg／片，粘合剂2.8 mg／片，膜衣厚度3. 0 mg／片（以片芯增重表示），硬脂酸镁 5%，及其制备工艺，并用HPLC对其休外释药情况进行了研究。结果表明：本制剂体外释药速度平稳， 在8h内呈现良好的零级释放特征，平均每小时释药0. 86 mg,基本上达到了预期的实脸目的，为新型药 物制剂——渗透泵型控释片的开发与应用奠定了一定的基础。

Formula and preparation methods of albutorol sulfate osmotic pump controlled release tablets were studied by orthogonal design test,and in vitro dissolutions of the prepared tablets were determined by HPLC in 0.9% NaCl solution. The results showed that the prepared tablets presented a good characteristics of zero order kinetics in 8 hours,and the average release rate was 0.86mg/h.The results of study met the experimental purposes and laid a foundation to some extent of the development and application of albutorol sulfate osmotic pump controlled release tablets.