采用薄层色谱法分别测定了3种国产大豆磷脂和进口蛋黄磷脂的组分，薄层条件选用硅胶 C板，点样量5μl，展开剂为氯仿一甲醇一水一冰醋酸(45：15：2：0.2).显色剂为7％的磷相酸乙醇液，检 测波长670 nm。分别选用4种磷脂采用薄膜载体沉积法制备前体脂质体，研究了4种不同磷脂组分对 脂质休的形成、结构和药物包封率的彩响。结果表明，磷脂中主要组分PC和LPC对脂质体的形成和包 封率彩响不大，而PE和PI是影响脂质体的形成和药物包封率的主要因素，磷脂的纯度高低与脂质体 制备本身和包封的好坏没有必然的关系。从而表明影响脂质体形成和包封的因素除所包封药物本身的 理化性质外、主要是所选用磷脂的组分．

A high performance silica gel G plate was developed with chloroform-methanol-water-acetic acid(45:15:2:0.2).7% phosphato-molybdic acid was used as development agent and the detection was at 670 nm.The method was used to separate the components of three soyabean phospholipids from different factories in China and one imported egg phospholipid. The proliposomes which contained different phospholipids were prepared by the carrier disposition of membrance respectively,and the effects of four different phospholipids on liposomal forming, structure and entrapment efficiency were studied. The effects of the main component such as phos-phatidylethanolamin (PE) and phosphatidyl-inosine(PI)on liposomal forming and entrapment efficiency were marked. In contrast to PE and PI,phosphatidylcholine(PC)and lysolecithin(LPC)had no effects on them.Liposomal forming and high entrapment efficiency had nothing to do with the purity of phospholipids.