摘要
实验表明，胸腺免疫抑制提取物8, 20, 50 和125 mg/kg对大鼠被动皮肤过敏反应有明显的
抑制作用。体外试验表明，该药能抑制致敏豚鼠离体回肠平滑肌的过敏性收缩，半数抑制浓度为446.7
mg/L,此外胸腺抑制提取物肌内注射，连续7 d,能明显抑制兔Arthus反应．上述试验表明胸腺免
疫抑制提取物有抗变态反应作用，
Abstract
The anti-allergic effects of thymic immunosuppressive extract from swine thymus were studied.The results showed that the extract shortened the diameter of blue spot of passive cutaneous anaphylaxis in rats and inhibited in vitro the anaphylactic contraction of guinea-pig ileum smooth muscle.The IC50 was 446.7mg/L.The extract also suppressed arthus reaction in rabbit.
关键词
胸腺免疫抑制提取物 /
地塞米松 /
变态反应 /
被动皮肤过敏反应
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Key words
thymic immunosuppressive extract /
passive cutaneous anaphylaxis /
dexamethasone /
allergy
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尚雪原;张世玲;焦波;程艳娜;鲁凤友;纪建波
.王凤山.
胸腺免疫抑制提取物抗变态反应作用研究[J]. 中国药学杂志, 1995, 30(S1): 19-20
Shng Xueyun;Zhng Shiling;Jio o;Cheng Ynn;Lu Fengyou;Ji Jino;Wng Fengshn.
Anti-allergic effects of thymic immunosuppressive extract[J]. Chinese Pharmaceutical Journal, 1995, 30(S1): 19-20
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参考文献
1 臧恒昌，张天民，王凤山，等．猪胸腺免疫抑制组分的生化性质和免疫活性．中国医药工业杂志，1992,23(10)：436.
2 隋小平，张天民．猪胸腺免疫抑制提取物的研究．山东医科大学学报．1989，27(2)，59
3徐叔云．卞如濂，陈修．药理实验方法学．第2版．北京：人民卫生出版社，1991，1196
4 竺心影主编．药理学．第3版．北京：人民卫生出版社,1993：415
5 Blazsek I. Inhibition of lymphocyte production via thymicfactors. Blut．1981．42：235.
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脚注
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