研究了胰岛素pO微粒剂的处方筛选及其对四氧嘧啶致糖尿病模型小鼠的降血糖作用。结果 表明：给予糖尿病模型小鼠剂量为6u/20g的含有表面活性剂与促吸收剂的胰岛素po微粒剂，在1h以 内能有效地使血糖降至正常范围，与同剂量的胰岛素sc相比，3.0h以前作用效果无显著性差异（P> 0. 05).3.0 h以后有显著差异(P<0. 05)，前者血糖仍维持正常水平并特续5h以上．在7. 0 u/20 g- 4. 0 u/20 g的剂量范围内，吸收不存在饱和现象。

The effectiveness of oral administration of insulin microspheres(IMS) was evaluated in alloxan-treated diabetic rabbits. Three doses were tested. The blood glucose levels were determined enzymatically by using the method of glucose oxidase. A significant difference in blood glucose level was noted after use of 6 u/20 g IMS when compared to control groups,and maintained for 5 hours.The hypoglycemic effect was linear with the doses of IMS within the range of 7.0u/20g～4.0u/20g. The findings may be of significance in the search for a suitable oral administration for insulin or perhaps other proteinaceous substances.