虾青素的神经保护作用机制研究进展

王玉敏, 葛永利, 赵丽楠, 杜冠华, 王洪权

中国药学杂志 ›› 2018, Vol. 53 ›› Issue (8) : 569-573.

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中国药学杂志 ›› 2018, Vol. 53 ›› Issue (8) : 569-573. DOI: 10.11669/cpj.2018.08.001
综 述

虾青素的神经保护作用机制研究进展

  • 王玉敏1a, 葛永利2, 赵丽楠1b, 杜冠华3*, 王洪权1c, 3*
作者信息 +

Recent Advances in Neuroprotective Mechanisms of Astaxanthin in Acute Brain Injury and Neurodegenerative Disease

  • WANG Yu-min1a, GE Yong-li2, ZHAO Li-nan1b, DU Guan-hua3*, WANG Hong-quan1c, 3*
Author information +
文章历史 +

摘要

虾青素是一种类胡萝卜素,是海洋生物体内主要的类胡萝卜素之一。具有多种生物学活性,包括抗氧化、抗炎和抗凋亡等药理学活性。最近越来越多研究显示,其具有神经保护作用。 近年来研究显示,其在体内、外具有广泛的神经保护作用,在脑缺血和神经退行性疾病中的神经保护作用取得了一定进展,笔者就对虾青素在脑缺血和神经退行性疾病中的基础研究进行了总结,归纳了其在实验动物及细胞实验水平药理学活性、可能的神经保护作用机制。

Abstract

Astaxanthin(3,3′-dihydroxy-β, β′-carotene-4,4′-dione,ATX), a xanthophyll carotenoid produced naturally and synthetically, is a red-orange carotenoid with unique cell membrane actions and diverse biological activities. The beneficial effects of astaxanthin are linked to its oxidative, anti-inflammatory, and anti-apoptotic characteristics. More importantly, there is evidence demonstrating that astaxanthin confers neuroprotective effects in experimental models of neurological diseases. In this review, we will provides up-to-date information on the neuroprotective properties of astaxanthin in mitigating neuropathy in acute brain injury and neurodegenerative disease,and discuss its mechanistic details relating preclinical studies.

关键词

虾青素 / 脑卒中 / 神经退行性疾病 / 神经保护

Key words

astaxanthin / stroke / neurodegenerative disease / neuroprotection

引用本文

导出引用
王玉敏, 葛永利, 赵丽楠, 杜冠华, 王洪权. 虾青素的神经保护作用机制研究进展[J]. 中国药学杂志, 2018, 53(8): 569-573 https://doi.org/10.11669/cpj.2018.08.001
WANG Yu-min, GE Yong-li, ZHAO Li-nan, DU Guan-hua, WANG Hong-quan. Recent Advances in Neuroprotective Mechanisms of Astaxanthin in Acute Brain Injury and Neurodegenerative Disease[J]. Chinese Pharmaceutical Journal, 2018, 53(8): 569-573 https://doi.org/10.11669/cpj.2018.08.001
中图分类号: R741.05   

参考文献

[1] GRIMMIG B, KIM S H, NASH K, et al. Neuroprotective mechanisms of astaxanthin: a potential therapeutic role in preserving cognitive function in age and neurodegeneration[J]. Geroscience, 2017, 39(1):19-32.
[2] WU H, NIU H, SHAO A, et al. Astaxanthin as a potential neuroprotective agent for neurological diseases[J]. Mar Drugs, 2015, 13(9):5750-5766.
[3] AMBATI R R, PHANG S M, RAVI S, et al. Astaxanthin:sources, extraction, stability, biological activities and its commercial applications--a review[J]. Mar Drugs, 2014, 12(1):128-152.
[4] ZULUAGA M, GUEGUEN V, LETOURNEUR D, et al. Astaxanthin-antioxidant impact on excessive reactive oxygen species generation induced by ischemia and reperfusion injury[J]. Chem Biol Interact, 2018, 279(1):145-158.
[5] ZULUAGA M, BARZEGARI A, LETOURNEUR D, et al. Oxidative stress regulation on endothelial cells by hydrophilic astaxanthin complex:chemical, biological, and molecular antioxidant activity evaluation[J]. Oxid Med Cell Longev, 2017, 2017:8073798.
[6] SHEN H, KUO C C, CHOU J, et al. Astaxanthin reduces ischemic brain injury in adult rats[J]. FASEB J, 2009, 23(6):1958-1968.
[7] HUSSEIN G, NAKAMURA M, ZHAO Q, et al. Antihypertensive and neuroprotective effects of astaxanthin in experimental animals[J]. Biol Pharm Bull, 2005, 28(1):47-52.
[8] YANAI H, ITO K, YOSHIDA H, et al. Antihypertensive effects of astaxanthin[J]. Integr Blood Press Control, 2008,1(1):1-3.
[9] SASAKI Y, KOBARA N, HIGASHINO S, et al. Astaxanthin inhibits thrombosis in cerebral vessels of stroke-prone spontaneously hypertensive rats[J]. Nutr Res, 2011, 31(10):784-789.
[10] PAN L, ZHOU Y, LI X F, et al. Preventive treatment of astaxanthin provides neuroprotection through suppression of reactive oxygen species and activation of antioxidant defense pathway after stroke in rats[J]. Brain Res Bull,2017,130(3):211-220.
[11] LEE D H, LEE Y J, KWON K H. Neuroprotective effects of astaxanthin in oxygen-glucose deprivation in SH-SY5Y cells and global cerebral ischemia in rat[J]. J Clin Biochem Nutr,2010,47(2):121-129.
[12] XUE Y, QU Z, FU J, et al. The protective effect of astaxanthin on learning and memory deficits and oxidative stress in a mouse model of repeated cerebral ischemia/reperfusion[J]. Brain Res Bull,2017,131(4):221-228.
[13] LU Y P, LIU S Y, SUN H, et al. Neuroprotective effect of astaxanthin on H2O2-induced neurotoxicity in vitro and on focal cerebral ischemia in vivo[J]. Brain Res,2010,1360(1):40-48.
[14] NAI Y, LIU H, BI X, et al. Protective effect of astaxanthin on acute cerebral infarction in rats[J]. Hum Exp Toxicol, 2017,doi:10.1177/960327117745693.
[15] WANG H Q, SUN X B, XU Y X, et al. Astaxanthin upregulates heme oxygenase-1 expression through ERK1/2 pathway and its protective effect against beta-amyloid-induced cytotoxicity in SH-SY5Y cells[J]. Brain Res, 2010,1360(1):159-167.
[16] CHANG C S, CHANG C L, LAI G H. Reactive oxygen species scavenging activities in a chemiluminescence model and neuroprotection in rat pheochromocytoma cells by astaxanthin, beta-carotene, and canthaxanthin[J]. Kaohsiung J Med Sci,2013,29(8):412-421.
[17] LOBOS P, BRUNA B, CORDOVA A, et al. Astaxanthin protects primary hippocampal neurons against noxious effects of Aβ-oligomers[J]. Neural Plast, 2016, 2016:3456783.
[18] WEN X, HUANG A, HU J, et al. Neuroprotective effect of astaxanthin against glutamate-induced cytotoxicity in HT22 cells:Involvement of the Akt/GSK-3β pathway[J]. Neuroscience, 2015,303(19):558-568.
[19] YE Q, ZHANG X, HUANG B, et al. Astaxanthin suppresses MPP(+)-induced oxidative damage in PC12 cells through a Sp1/NR1 signaling pathway[J]. Mar Drugs, 2013, 11(4):1019-1034.
[20] YE Q, HUANG B, ZHANG X, et al. Astaxanthin protects against MPP(+)-induced oxidative stress in PC12 cells via the HO-1/NOX2 axis[J]. BMC Neurosci, 2012, 13:156.
[21] LEE D H, KIM C S, LEE Y J. Astaxanthin protects against MPTP/MPP+-induced mitochondrial dysfunction and ROS production in vivo and in vitro[J]. Food Chem Toxicol, 2011, 49(1):271-280.
[22] CHAN K C, MONG M C, YIN M C. Antioxidative and anti-inflammatory neuroprotective effects of astaxanthin and canthaxanthin in nerve growth factor differentiated PC12 cells[J]. J Food Sci, 2009, 74(7):225-231.
[23] LIU X, OSAWA T. Astaxanthin protects neuronal cells against oxidative damage and is a potent candidate for brain food[J]. Forum Nutr, 2009, 61(4):129-135.
[24] LIU X, SHIBATA T, HISAKA S, et al. Astaxanthin inhibits reactive oxygen species-mediated cellular toxicity in dopaminergic SH-SY5Y cells via mitochondria-targeted protective mechanism[J]. Brain Res, 2009, 1254(8):18-27.
[25] IKEDA Y, TSUJI S, SATOH A, et al. Protective effects of astaxanthin on 6-hydroxydopamine-induced apoptosis in human neuroblastoma SH-SY5Y cells[J]. J Neurochem, 2008, 107(6):1730-1740.
[26] LIU X, OSAWA T. Cis astaxanthin and especially 9-cis astaxanthin exhibits a higher antioxidant activity in vitro compared to the all-trans isomer[J]. Biochem Biophys Res Commun, 2007,357(1):187-193.
[27] LIU X, LUO Q, CAO Y, et al. Mechanism of different stereoisomeric astaxanthin in resistance to oxidative stress in Caenorhabditis elegans[J]. J Food Sci, 2016, 81(9):2280-2287.
[28] ZOU T B, ZHU S S, LUO F, et al. Effects of astaxanthin on reverse cholesterol transport and atherosclerosis in mice[J]. Biomed Res Int, 2017, 2017:4625932.
[29] AL S M, HEALES S, HARGREAVES I, et al. Oxidative stress:mechanistic insights into inherited mitochondrial disorders and Parkinson′s disease[J]. J Clin Med, 2017, 6(11):100.DOI:10.3390/jcm6110100.
[30] JIANG T, SUN Q, CHEN S. Oxidative stress:a major pathogenesis and potential therapeutic target of antioxidative agents in Parkinson′s disease and Alzheimer′s disease[J]. Prog Neurobiol, 2016,147(9):1-19.
[31] SUBRAMANIAM S R, CHESSELET M F. Mitochondrial dysfunction and oxidative stress in Parkinson′s disease[J]. Prog Neurobiol, 2013,106-107(6):17-32.
[32] HAUSER D N, HASTINGS T G. Mitochondrial dysfunction and oxidative stress in Parkinson′s disease and monogenic parkinsonism[J]. Neurobiol Dis, 2013, 51(6):35-42.
[33] WANG Y M, WANG Y H, DU G H, et al. Research progress of targeting HO-1/NOX2 pathway for the treatment of Parkinson′s disease[J]. Chin Pharm J(中国药学杂志), 2015, 50(23):2024-2027.
[34] UNGERSTEDT U. Postsynaptic supersensitivity after 6-hydroxy-dopamine induced degeneration of the nigro-striatal dopamine system[J]. Acta Physiol Scand Suppl, 1971,82(5367):69-93.
[35] ZHANG X S, ZHANG X, WU Q, et al. Astaxanthin alleviates early brain injury following subarachnoid hemorrhage in rats:possible involvement of Akt/bad signaling[J]. Mar Drugs, 2014, 12(8):4291-4310.
[36] WU Q, ZHANG X S, WANG H D, et al. Astaxanthin activates nuclear factor erythroid-related factor 2 and the antioxidant responsive element(Nrf2-ARE) pathway in the brain after subarachnoid hemorrhage in rats and attenuates early brain injury[J]. Mar Drugs, 2014, 12(12):6125-6141.
[37] LI Z, DONG X, LIU H, et al. Astaxanthin protects ARPE-19 cells from oxidative stress via upregulation of Nrf2-regulated phase Ⅱ enzymes through activation of PI3K/Akt[J]. Mol Vis, 2013, 19(4):1656-1666.

基金

国家自然科学基金项目资助(81260196,81450036,71704053);内蒙古自治区高等学校青年科技英才支持计划资助(NJYT-17-B23);内蒙古自然科学基金项目资助(2015BS0812,2017MS0867,2017MS0868); 内蒙古自治区高等学校科学研究项目资助(NJZY234);“草原英才”工程计划资助; “内蒙古自治区青年创新人才”计划资助; 内蒙古自治区新世纪321人才工程计划资助;赤峰学院药理学重点实验室项目资助(ZDSYS201404)
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