Basic & Clinical Medicine ›› 2010, Vol. 30 ›› Issue (7): 683-688.
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Kuo CHEN, Zhan-sen XIAO, Hui-dong DOU, Shu-qin HOU, Yue-feng LIU, Xiao-ming TAO, Feng LI, Chang-chun QIU
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Abstract: Objective To investigate the relationship between polymorphism of the APOB gene and stroke in Han Chinese population.Methods This study was a population-based cross-sectional case-control study. In APOB gene, the polymorphisms of C7673T and 5′I/D were determined by Polymerase Chain Restriction-Restriction Fragment Length Polymorphism (PCR-RFLP) and sequencing in 547 patients with ischemie stroke (466 ischemie stroke) and 886 controls. Results The distributions of C7673T (p=0.6293) and 5′I/D (p=0.5359) genotype frequencies in men and women were in accordance with the Hardy-Weinberg equilibrium. In C7673T locus, the genotype CC frequency in females was significant lower in ischemic stroke than that in healthy controls (p<0.01), and allele C frequency was significant lower in ischemic stroke than that in healthy controls (p<0.01). But significant differences were not found in males. The frequency of genotype II at 5′I/D locus in males was significant lower in cerebral hemorrhage patients than that in healthy controls (p<0.01). The frequency of genotype II and the allele I at 5′I/D locus in males was significant lower in ischemic stroke patients than that in healthy controls(p<0.01). The frequency of genotype II and the allele I at 5′I/D locus in females was also significant lower in ischemic stroke patients than that in healthy controls, (p<0.01,p<0.05,respectively)Conclusion The C7673T polymorphism of APOB gene associates with ischemic stroke in Fangshan district in female. The 5′I/D polymorphism of APOB gene associates with ischemic stroke in Fangshan district in male and female.
Key words: ApoB gene, stroke, cerebral hemorrhage, ischemic stroke, polymorphism
Kuo CHEN; Zhan-sen XIAO; Hui-dong DOU; Shu-qin HOU; Yue-feng LIU; Xiao-ming TAO; Feng LI; Chang-chun QIU. Relationship between the APOB gene polymorphism and stroke in China Fanshan district[J]. Basic & Clinical Medicine, 2010, 30(7): 683-688.
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