Abstract: It is a key problem that the survival rate of stem cells is low in the ischemic myocardium microenvironment when treating ischemic diseases with stem cell transplantation. It is able to increase anti-apoptotic ability of the stem cells and promote their effective differentiation towards myocardial cells directly and indirectly by pretreating the stem cells with cytokines, drugs or chemical compounds, or modifying gene expression to promote cell adhesion, survival or angiogenesis for repairing ischemic myocardium and improving heart function after transplantation of the stem cells.

Key words: stem cell, survival, cardiac repair