Abstract: abstract objective: to study the effect of PPAR- ligand RGZ on expression in transplantation tumor of Cholangiocarcinoma . Method: interfere the nude mice bearing cancer of Cholangiocarcinoma with RGZ in different concentration and dosages, sacrificed them after 3 week intragastric administration. Measure the tumor volumes and weights, evaluate the relative tumor volume, relative tumor increasing ratio T/C%; detect the expression of PPAR-冏 by RT-PCR by Real Time Fluorescent Quantitation, statistic analysis as well. Result: following the dose of RGZ raising the expression of PPAR-, while the tumor volumes, weights , the relative tumor increment ratio T/C% decrease in the transplantation tumor of Cholangiocarcinoma. Statistic treatments show there is no significance between control and low dose groups, P>0.05; but comparing with high dose group there is obvious significance, P<0.001. Conclusionin vivo,the RGZ can show obvious effect of up-regulation PPAR- expression in transplantation tumor of Cholangiocarcinoma .

Key words: peroxisome proliferactor-activated receptor gamma, PPAR-γ, rosiglitazone, RGZ, Cholangiocarcinoma