Abstract: Abstract: Myocardial infarction is one of the main factors causing heart failure that is associated with a high rate of morbidity and mortality in the developing countries. Due to infracted cardiac muscles, heart function will aggravate and myocardium will remodel all that lead to exacerbation of the disease. Current treatment modalities may not be adequate to prevent myocardial remodeling. It is necessary to explore a new way to restore the damaged myocardium. Stem cell-based therapy, which is developing rapidly, has been used in the field of cardiovascular disease. There are many problems still to be solved.