Abstract: Objective To evaluate the efficacy of acute coronary arterial clot disruption by intravenous administration of self-restraint thrombus target ultrasound microbubbles(TMB). Methods Thrombus was formed in the left descent coronary artery by electrical stimulation in 25 dogs．After thrombolysis，dogs were received treatment by transcutaneous ultrasound (1MHz、2.0W/cm2) and TMB or albumin microbubbles (AMB). The vessel recanalization times were recorded and the areas of residual thrombus and infarction were compared by pathological section. Results TMB intravenous administrated resulting in the quick recovery of arterial embolism and decreased the thrombus ratio of residual thrombus cross-sessional and infarction area compared with AMB groups. The effect of thrombolysis was significantly progressed in TMB plus half dose urokinase group and even better than urokinase only groups. Conclusions The thrombolytics activity of TMB was superior to AMB．Combined with TMB in thrombolytic therapy can help to decreased the dose of urokinase.