Abstract: Objective To study relationship between ghrelin gene polymorphisms and type 2 diabetes and its risk factors.Methods All subjects were genotyped for these two single nucleotide polymorphisms (C408A, G346A) of ghrelin by PCR-RFLP assay. Anthropometric variables, blood glucose, insulin, lipid, uric acid and other clinic parameters were measured.Result In control group, the genotype frequencies as follows: CC 75.4%(n=251), CA 24%(n=80), and AA 0.6%(n=2). In type 2 diabetes group, the genotype frequencies: CC 70.8%(n=143), CA 28.2%(n=57), and AA 1.0(n=2). There were no significant differences of the genotype frequencies in two groups. In control group, serum total cholesterol in subjects carrying CC genotype is higher than subjects not carrying CC genotype ((P<0.05); in type 2 diabetes groups, serum uric acid in subjects carrying CC genotype is higher than subjects not carrying CC genotype ((P<0.05).There were not G346A variants existed in our study subjects.Conclusion The allele frequencies and genotype distribution of the C408A did not differ significantly among control and type 2 diabetes groups; G346A polymorphisms were not existed in control and type 2 diabetes groups. C408A variants associated with total cholesterol and uric acid.