Abstract: Proteomic research first came to the fore with the introduction of two-dimensional gel electrophoresis and proteomics has been increasingly applied to cancer research with the wide-spread introduction of mass spectrometry and protein chip. As important research tools, oncoproteomics that targets the entire cancer-specific protein network has already been applied in cancer research .In this article the development of the oncoproteomics and its applying in cancer is reviewed.

Key words: Oncoproteomics two dimensional electrophoresis mass spectrometry protein chip