Abstract: Objective To investigate the effect of low-intensity ultrasound on intraocular hypertension and its mechanicsm． Methods　 The intraocular hypertension rabbits were treated with ultrasound .The intraocular pressure(IOP), trabecular meshwork HE staining ,transmission electron microscope, extracellular matrix through immunohistochemistry were observed．　Results　After treatment, IOP was descended and trabecula interspace was wider than the control eye. The expression of collagen I,laminin and fibronectin was lower than control group. Conclusion　Low-intensity ultrasound can decrease IOP. It maybe relate with the change of trabecular meshwork histologic structure .