Abstract: Objective To study the effects of Fluvastatin on the expression of intercellular adhesion molecule-1 (ICAM-1) in human umbilical vein endothelial cells (HUVECs) induced by C-reactive protein (CRP). Method The HUVECs were primary cultured . HUVECs of the third to fifth generations were stimulated in different concentration CRP of 5,10,50 and 100mg/L and different time of 6, 12 and 24h. Then the cells were treated with Fluvastatin in different concentration of 10-7,10-6 and 10-5mol/L. The content of ICAM-1 protein was detected with ELISA, the mRNA expression of ICAM-1 was evaluated by RT-PCR. Results In the control group, HUVECs produce ICAM-1 protein and mRNA in low concentrations. In the CRP group, the content of ICAM-1 protein was increased significantly (p<0.01) and the mRNA expression of ICAM-1 was increased significantly (p <0.01). The increasing effect of ICAM-1 protein was concentration -dependent and time- dependent (p<0.01). In the Fluvastatin group, the content of ICAM-1 protein and the mRNA expression of ICAM-1 was decreased significantly (p<0.01). The inhibitory effects of fluvastatin on ICAM-1 protein was concentration -dependent (p<0.05). Conclusion Fluvastatin maybe exert the function of anti- atherosclerosis by inhibiting the expression of ICAM-1 induced by CRP in HUVECs.