Basic & Clinical Medicine ›› 2023, Vol. 43 ›› Issue (1): 169-173.doi: 10.16352/j.issn.1001-6325.2023.01.0169

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Research progress of targeting on Nrf2/ARE pathway in the treatment of ischemic stroke

YANG Xiaofei1, LI Qiang1*, LI Yanfeng2, WANG Hongquan3   

  1. 1. Department of Neurology, the Affiliated Hospital of Chifeng University, Chifeng 024005;
    2. Department of Neurology, Peking Union Medical College Hospital, CAMS & PUMC, Beijing 100050;
    3. Department of Neurology, Aerospace Center Hospital, Peking University Aerospace School of Clinical Medicine, Beijing 100049, China
  • Received:2021-05-10 Revised:2021-12-08 Published:2022-12-27
  • Contact: *

Abstract: Recently, mounting evidences have suggested the therapeutic potential of Nrf2/ARE activators for treating Ischemic stroke. Moreover, several Nrf2 activators attenuate ischemic stroke-induced brain injury in several transient focal cerebral ischemia (tMCAO) in experimental animal models.

Key words: ischemic stroke, NF-E2-related factor 2(Nrf2), natural compounds, transient focal cerebral ischemia

CLC Number: