Correlation between susceptibility to chronic obstructive pulmonary disease and single nucleotide polymorphisms

doi:10.16352/j.issn.1001-6325.2022.12.1891

Abstract

Abstract: Objective To investigate the correlation between single nucleotide polymorphism (SNP) and susceptibility of chronic obstructive pulmonary disease (COPD). Methods A total of 444 COPD patients and 434 healthy people were selected as the research objects. The Sequenom MassARRAY typing was performed at four loci of chitotriosidase-1(CHIT1): rs771576027, rs1402870472, rs61745299 and rs527497633, and a site rs117292391 on phosphodiesterase 4D(PDE4D). The correlation between single nucleotide polymorphism (SNP) and the risk of COPD was statistically evaluated. Results Genotype CG and allele C of rs61745299(CHIT1) increased the risk of COPD, and the distribution frequency was significantly different (P＜0.05). Genotype AG and allele G of rs117292391(PDE4D) also increased the risk of COPD with significant, distribution frequency(P＜0.05). Smoking also increased the risk of COPD. Conclusions rs61745299(CHIT1) and rs117292391 (PDE4D) are potential candidates of COPD biomarkers.

Key words: chronic obstructive pulmonary disease, chitinase 1, phosphodiesterase 4D, single nucleotide polymorphism

CLC Number:

XIA Cen-feng, WANG Na, ZHANG Peng. Correlation between susceptibility to chronic obstructive pulmonary disease and single nucleotide polymorphisms[J]. Basic & Clinical Medicine, 2022, 42(12): 1891-1894.

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URL: http://journal11.magtechjournal.com/Jwk_jcyxylc/EN/10.16352/j.issn.1001-6325.2022.12.1891

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