Abstract: Objective To analyze the correlation between the classification of infection by delta variant of coronavirus disease 2019(COVID-19 delta) in Zhangjiajie City and the differences in general health conditions and clinical characteristics of confirmed cases. Methods Seventy-three confirmed patients admitted to Zhangjiajie People's Hospital from July 20, 2021 to September 30, 2021 were enrolled into this research project. According to the diagnostic and typing criteria of Novel Coronavirus Protocol for the Diagnosis and Treatment of Pneumonia (Trial Edition 8), the patients were classified as mild, ordinary and severe groups and compared for general condition, clinical manifestations and laboratory data. Results Of the 73 patients, 22 (30.1%) were in the mild group and 51 (69.9%) were in the normal and severe groups. There were statistically significant differences in age, gender, globulin, albumin, fibrinogen, amyloid A, C-reactive protein, ESR and D-dimer between the two groups (P＜0.05).Binary Logistic regression analysis showed that serum albumin was an independent influencing factor for common/severe group (OR=0.762,95% CI:0.585~0.993, P＜0.05). Conclusions Serum albumin is a protective factor for infection by common/severe COVID-19 delta variant. Albumin supplementation may play an important role in the prevention of ordinary/severe of COVID-19 delta.

Key words: coronavirus disease 2019, delta variant of novel-coronavirus, serum albumin