| [1] |
Newling M, Sritharan L, Van Der Ham AJ, et al. C-reactive protein promotes inflammation through fcγr-induced glycolytic reprogramming of human macrophages[J]. J Immunol, 2019, 203: 225-235.
|
| [2] |
Huang J, Cai C, Zheng T, et al. Endothelial scaffolding protein enh (enigma homolog protein) promotes phlpp2 (pleckstrin homology domain and leucine-rich repeat protein phosphatase 2)-mediated dephosphorylation of akt1 and enos (endothelial no synthase) promoting vascular remodeling[J]. Arterioscler Thromb Vasc Biol, 2020, 40: 1705-1721.
|
| [3] |
Li P, Wang J, Zhao X, et al. Pten inhibition attenuates endothelial cell apoptosis in coronary heart disease via modulating the ampk-creb-mfn2-mitophagy signaling pathway[J]. J Cell Physiol, 2020, 235: 4878-4889.
|
| [4] |
Li FP, Lin DQ, Gao LY. LncRNA tug1 promotes proliferation of vascular smooth muscle cell and atherosclerosis through regulating mirna-21/pten axis[J]. Eur Rev Med Pharmacol Sci, 2018, 22: 7439-7447.
|
| [5] |
Xu CX, Xu L, Peng FZ, et al. miR-647 promotes proliferation and migration of ox-ldl-treated vascular smooth muscle cells through regulating PTEN/PI3K/AKT pathway[J]. Eur Rev Med Pharmacol Sci, 2019, 23: 7110-7119.
|
| [6] |
Islam S, Yoshioka K, Aki S, et al. Class Ⅱ phosphatidylinositol 3-kinase α and β isoforms are required for vascular smooth muscle rho activation, contraction and blood pressure regulation in mice[J]. J Physiol Sci, 2020, 70: 18. doi: 10.1186/s12576-020-00745-2.
|
| [7] |
Lin T, Ruan S, Huang D, et al. MeHg-induced autophagy via jnk/vps34 complex pathway promotes autophagosome accumulation and neuronal cell death[J]. Cell Death Dis, 2019, 10: 399. doi: 10.1038/s41419-019-1632-z.
|
| [8] |
杨卉, 莫显刚, 王兰, 等. Apoe~(-/-)小鼠动脉粥样硬化斑块中nhe1与netrin-1表达上调[J].基础医学与临床, 2020, 40: 777-783.
|
| [9] |
Zheng Z, Zeng Y, Zhu X, et al. Apom-s1p modulates ox-ldl-induced inflammation through the PI3K/AKT signaling pathway in huvecs[J]. Inflammation, 2019, 42: 606-617.
|
| [10] |
Yan H, Ma Y, Li Y, et al. Insulin inhibits inflammation and promotes atherosclerotic plaque stability via PI3K-AKT pathway activation[J]. Immunol Lett, 2016, 170: 7-14.
|
| [11] |
Jiang L, Qiao Y, Wang Z, et al. Inhibition of microrna-103 attenuates inflammation and endoplasmic reticulum stress in atherosclerosis through disrupting the pten-mediated mapk signaling[J]. J Cell Physiol, 2020, 235: 380-393.
|
| [12] |
Zhang X, Wang L, Peng L, et al. Dihydromyricetin protects huvecs of oxidative damage induced by sodium nitroprusside through activating PI3K/AKT/foxO3a signalling pathway[J]. J Cell Mol Med, 2019, 23: 4829-4838.
|
| [13] |
Gu L, Ye P, Li H, et al. Lunasin attenuates oxidant-induced endothelial injury and inhibits atherosclerotic plaque progression in apoE(-/-) mice by up-regulating heme oxygenase-1 via PI3K/AKT/NRF2/are pathway[J]. Faseb J, 2019, 33: 4836-4850.
|
| [14] |
Zhou PL, Li M, Han XW, et al. Perilipin 5 deficiency promotes atherosclerosis progression through accelerating inflammation, apoptosis, and oxidative stress[J]. J Cell Biochem, 2019, 120: 19107-19123.
|
| [15] |
Babaev VR, Ding L, Zhang Y, et al. Loss of 2 AKT(protein kinase b) isoforms in hematopoietic cells diminished monocyte and macrophage survival and reduces atherosclerosis in ldl receptor-null mice[J]. Arterioscler Thromb Vasc Biol, 2019, 39: 156-169.
|
| [16] |
Song N, Jia L, Cao H, et al. Gypenoside inhibits endothelial cell apoptosis in atherosclerosis by modulating mitochondria through PI3K/AKT/BAD pathway[J]. Biomed Res Int, 2020, 2020: 2819658. doi: 10.1155/2020/2819658.
|
| [17] |
Wang Z, Bao Z, Ding Y, et al. Nε-carboxymethyl-lysine-induced PI3K/AKT signaling inhibition promotes foam cell apoptosis and atherosclerosis progression[J]. Biomed Pharmacother, 2019, 115: 108880. doi: 10.1016/j.biopha.2019.108880.
|
| [18] |
Jamuna S, Ashokkumar R, Sakeena Sadullah MS, et al. Oligomeric proanthocyanidins and epigallocatechin gallate aggravate autophagy of foam cells through the activation of class Ⅲ PI3K/beclin1-complex mediated cholesterol efflux[J]. Biofactors, 2019, 45: 763-773.
|
| [19] |
Zhai C, Cheng J, Mujahid H, et al. Selective inhibition of pi3k/akt/mtor signaling pathway regulates autophagy of macrophage and vulnerability of atherosclerotic plaque[J]. PLoS One, 2014, 9: e90563. doi: 10.1371/journal.pone.0090563.
|
| [20] |
Miao W, Yan Y, Bao TH, et al. Ischemic postcondition-ing exerts neuroprotective effect through negatively regulating pi3k/akt2 signaling pathway by microrna-124[J]. Biomed Pharmacother, 2020, 126: 109786. doi: 10.1016/j.biopha.2019.109786.
|
| [21] |
Durham KK, Chathely KM, Trigatti BL. High-density lipoprotein protects cardiomyocytes against necrosis induced by oxygen and glucose deprivation through sr-b1, pi3k, and akt1 and 2[J]. Biochem J, 2018, 475: 1253-1265.
|
| [22] |
Pi S, Mao L, Chen J, et al. The p2ry12 receptor promotes vsmc-derived foam cell formation by inhibiting autophagy in advanced atherosclerosis[J]. Autophagy, 2020, 1-21.
|
| [23] |
Li B, Fang J, He T, et al. Resistin up-regulates lpl expression through the pparγ-dependent PI3K/AKT signaling pathway impacting lipid accumulation in raw264.7 macrophages[J]. Cytokine, 2019, 119: 168-174.
|
| [24] |
Li M, Li M, Yang Y, et al. Remodeling tumor immune microenvironment via targeted blockade of PI3K-γ and csf-1/csf-1r pathways in tumor associated macrophages for pancreatic cancer therapy[J]. J Control Release, 2020, 321: 23-35.
|
| [25] |
Fougerat A, Gayral S, Gourdy P, et al. Genetic and pharmacological targeting of phosphoinositide 3-kinase-gamma reduces atherosclerosis and favors plaque stability by modulating inflammatory processes[J]. Circulation, 2008, 117: 1310-1317.
|
| [26] |
Liu F, Qiu H, Xue M, et al. Msc-secreted TGF-β regulates lipopolysaccharide-stimulated macrophage M2-like polarization via the AKT/FoxO1 pathway[J]. Stem Cell Res Ther, 2019, 10: 345. doi: 10.1186/s13287-019-1447-y.
|
| [27] |
Liu Y, Tie L. Apolipoprotein m and sphingosine-1-phosphate complex alleviates tnf-α-induced endothelial cell injury and inflammation through PI3K/AKT signaling pathway[J]. BMC Cardiovasc Disord, 2019, 19: 279. doi: 10.1186/s12872-019-1263-4.
|
| [28] |
Ma Q, Zhang W, Zhu C, et al. FUNDC2 regulates platelet activation through AKT/GSK-3β/cGMP axis[J]. Cardiovasc Res, 2019, 115: 1672-1679.
|
| [29] |
Zheng Y, Lv P, Huang J, et al. GYY4137 exhibits anti-atherosclerosis effect in apolipoprotein E(-/-) mice via PI3K/AKT and TLR4 signalling[J]. Clin Exp Pharmacol Physiol, 2020, 47: 1231-1239.
|
