Basic & Clinical Medicine ›› 2022, Vol. 42 ›› Issue (8): 1310-1313.doi: 10.16352/j.issn.1001-6325.2022.08.1310

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Function of the microglia in neuroinflammation of Alzheimer's disease:a brief review

WANG Yuan-zhuo1,2, ZHENG Qing-yue1,2, ZHANG Han-lin1,2, QIU Wen-ying1, WANG Tao1, MA Chao1*   

  1. 1. Department of Anatomy,Histology and Embryology,Institute of Basic Medical Sciences CAMS, School of Basic Medicine PUMC,Beijing 100005;
    2. Eight-year Program of Clinical Medicine,Department of Clinical Medicine, Peking Union Medical College,Beijing 100730,China
  • Received:2020-12-17 Revised:2021-07-19 Online:2022-08-05 Published:2022-08-01
  • Contact: *

Abstract: Different types of activated imbroglio exist in the brain of the patients with Alzheimer's disease (AD). As the neuroinflammation reaction progresses, significant changes take place in the morphology and function of those cells. They could play a pathogenic role by altering the phagocytic function of cells, including intracellular toxic reactions or directly participate in immune response. Several clinical trials have been conducted to promote targeted therapy focusing on the role that microglia played in neuroinflammation reactions of AD. More large scale studies are necessary to elucidate the function and mechanism of microglia in the neuroinflammation reaction of AD.

Key words: Alzheimer's disease, microglia, neuroinflammation

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