Basic & Clinical Medicine ›› 2022, Vol. 42 ›› Issue (7): 1119-1123.doi: 10.16352/j.issn.1001-6325.2022.07.1119

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Research advances in the role of interferon regulatory factor 4(IRF4) in chronic inflammatory diseases

LUAN Ge1,2, WANG Ming1,2, WANG Cheng-shuo1,2*, ZHANG Luo1,2, 3*   

  1. 1. Department of Otolaryngology Head and Neck Surgery, Key Laboratory of Otolaryngology Head and Neck Surgery of Ministry of Education; 3. Department of Allergology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730;
    2. Beijing Institute of Otolaryngology, Beijing Key Laboratory of Nasal Diseases, Beijing 100005, China
  • Received:2021-01-26 Revised:2021-07-12 Online:2022-07-05 Published:2022-06-29
  • Contact: *;

Abstract: Interferon regulatory factor 4 (IRF4) is expressed in a variety of immune cells and participates in the regulation of a variety of immune responses. IRF4 is related to a variety of chronic inflammatory diseases and respiratory allergic diseases. Inhibiting the expression or the function of IRF4 can reduce or delay the occurrence and development of the disease. Studying the role and mechanism of IRF4 in chronic rhinopathy and airway allergic diseases will help provide new strategies for disease treatment.

Key words: interferon regulatory factor 4, chronic inflammatory disease, respiratory allergic disease, immune regulation

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