Basic & Clinical Medicine ›› 2021, Vol. 41 ›› Issue (1): 116-119.

• Mini Reviews • Previous Articles     Next Articles

Research advance on telomere shortening and bone marrow failure diseases

GAO Xiao-yan, LIU Shu-chuan*   

  1. Department of Hematology, the First Affiliated Hospital of Harbin Medical University, Harbin 150001, China
  • Received:2019-10-24 Revised:2020-01-27 Online:2021-01-05 Published:2020-12-30
  • Contact: *

Abstract: Telomere shortening is an important pathogenesis of bone marrow failure diseases. As a therapeutic target, telomere may become a new research direction for bone marrow failure diseases. Telomere shortening is related to clinical acquired bone marrow failure diseases, including aplastic anemia, myelodysplastic syndrome and immune mechanism related pancytopenia. The relation between telomere shortening and some inherited bone marrow failure diseases, including dyskeratosis congenita, fanconi anemia is also referred.

Key words: telomere shortening, genetic mutations, bone marrow failure diseases, aplastic anemia, myelodysplastic syndrome

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