Abstract: Objective To understand the characteristics of patients with blood disease and chronic subdural hematoma.,and the effect of blood disease on the treatment of chronic subdural hematoma. To guide the treatment of patients who both with blood disease and chronic subdural hematoma.Methods Through a retrospective study of the cases of chronic subdural hematoma from January 1, 2000 to June 1, 2017 in Peking Union Medical College Hospital, the following items were investigated. 1).According to whether or not they were associated with blood disease, the collected cases were divided into the blood disease group and the non-blood disease group. And the clinic data of the sex composition, average ages, treatment effect and mortality were compared.2). According to the treatment, the cases with Blood disease were divided into the surgical group and the conservative group. And the treatment effect and mortality were compared. Results A total of 433 patients with chronic subdural hematoma were included in this study, including 35 patients associated with blood diseases.1) . Compared to the non-blood disease group, the patients in the blood disease group were younger(P＜0.01);the male ratio was lower （P＜0.01）; the treatment effect was lower(P＜0.001) and the mortality was higher(P＜0.001). 2). Within the patients with blood disease, the surgical group had the better treatment effect(78.9%vs31.3%，P＜0.01) and the lower mortality(15.8%vs50.0%，P＜0.01). Conclusions 1).The patients in the blood disease group are younger and the male ratio is lower than the non-blood disease group; 2). The blood disease is a risk factor for the treatment of Chronic Subdural Hematoma; 3). The patients who both with the blood disease and the Chronic Subdural Hematoma should be treated by surgery.

Key words: the blood disease, the Chronic Subdural Hematoma, surgical treatment, effective rate, mortality rate